Advances in Vaccines
Advances in Vaccines
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DOI：
10.1007/10_2019_107
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发表时间：
2020-01-01
期刊：
影响因子：
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通讯作者：
Chao, Shoubai
中科院分区：
文献类型：
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作者：
Mao, Helen H.;Chao, Shoubai
疫苗代表了科学和医学最重要的进步之一，帮助世界各地的人们预防传染病的传播。然而，许多国家的疫苗接种计划仍存在差距。在欧盟地区出生的1120万儿童中，有50多万婴儿在一岁生日前没有接受完整的白喉、百日咳和破伤风三剂系列疫苗。数据显示，近年来欧洲地区有3万多例麻疹病例，美国的麻疹病例正在上升。世界上大约有2000万儿童仍然没有得到足够的基本疫苗。疟疾、埃博拉病毒病和寨卡病毒病等新出现的传染病也威胁着世界各地的公共卫生。本章概述了疫苗开发和技术、生产、各种疫苗的表征、挑战和疫苗临床开发策略的最新进展。它还概述了最近批准的主要人用疫苗。[图形]。
Vaccines represent one of the most important advances in science and medicine, helping people around the world in preventing the spread of infectious diseases. However, there are still gaps in vaccination programs in many countries. Out of 11.2 million children born in EU region, more than 500,000 infants did not receive the complete three-dose series of diphtheria, pertussis, and tetanus vaccine before the first birthday. Data shows that there were more than 30,000 measles cases in the European region in recent years, and measles cases are rising in the USA. There are about 20 million children in the world still not getting adequate coverage of basic vaccines. Emerging infectious diseases such as malaria, Ebola virus disease, and Zika virus disease also threaten public health around the world. This chapter provides an overview of recent advances in vaccine development and technologies, manufacturing, characterization of various vaccines, challenges, and strategies in vaccine clinical development. It also provides an overview of recently approved major vaccines for human use.[GRAPHICS].