Radiation-therapy effects on bone density
Radiation-therapy effects on bone density
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DOI：
10.1002/mpo.10338
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发表时间：
2003-09-01
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影响因子：
--
通讯作者：
Hopewell, JW
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文献类型：
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作者：
Hopewell, JW
关于放射治疗对接受恶性肿瘤治疗的儿童骨中矿物质含量的影响，现有数据有限。骨质减少的发生率在8%到23%之间，但混杂因素是化疗的使用和预防性颅照射的影响。影响骨萎缩的因素在接受高剂量局部放射治疗的成年癌症患者中没有更明确的定义。在患者组织中观察到的病理学结果表明，血管变化在骨质减少的发生中具有明确的作用，尽管成骨细胞损失的影响仍存在一些不确定性。在实验动物研究中，骨血流量减少明显与剂量有关，单次剂量>20戈伊后，骨矿物质含量发生变化，但这仅发生在照射后的晚期（大于或等于30周）。由于许多动物研究的局限性，这些变化与骨强度之间的关系尚未得到证实。乳腺癌患者肋骨骨折的辐射剂量分级数据表明α/β比值在1.8-2.8戈伊范围内，与其他晚期反应正常人体组织获得的值相当。(C)2003 Wiley-Liss，Inc.
Only limited data are available on the effects of radiation-therapy on the mineral content of the bone of children treated for malignancy. The incidence of osteopenia varies between 8 and 23%, but confounding factors were the use of chemotherapy and the effects of prophylactic cranial irradiation. The factors influencing bone atrophy are no more clearly defined in adults treated for cancer by high dose local radiation-therapy. Pathological observed in patient tissues, indicates a clear role for vascular changes in the development of osteopenia, although there remains some uncertainty as to the effects of osteoblast cell loss. Reduced blood flow in bone is clearly dose-related in experimental animal studies and after single doses of >20 Gy changes in bone mineral content have been found. However, this was only at late times (greater than or equal to30 weeks) after irradiation. The relationship between these changes and bone strength remains unproven because of the limited nature of many of the animal studies. Radiation dose fractionation data for rib-fracture in breast cancer patients suggests an alpha/beta ratio is in the range 1.8-2.8 Gy, comparable to values obtained for other late responding normal human tissues. (C) 2003 Wiley-Liss, Inc.