Behavioral and cardiovascular consequences of disrupted oxytocin communication in cohabitating pairs of male and female prairie voles
Behavioral and cardiovascular consequences of disrupted oxytocin communication in cohabitating pairs of male and female prairie voles
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DOI：
10.1080/17470919.2019.1572031
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发表时间：
2019-11-02
影响因子：
2
通讯作者：
Dagner, Ashley
中科院分区：
文献类型：
--
作者：
Grippo, Angela J.;McNeal, Neal;Dagner, Ashley
负面的社会经验可能会影响心理和生理健康，通过改变中央催产素通信。草原田鼠对于研究催产素对社会经验反应的潜在影响很有价值。草原田鼠是社会性的一夫一妻制，成对或家庭群体生活，并对社会环境的变化做出负面反应。这项研究调查的假设，催产素在一个草原田鼠的同居男女对中断会改变社会行为，在特定的动物，这些行为的变化反过来又会影响未经处理的合作伙伴？的行为和生理。催产素与受体拮抗剂L-368，899在雄性草原田鼠中的药理学拮抗作用破坏了雄性和未治疗的雌性伴侣之间的社会行为。这种操作也对未治疗的女性伴侣的行为和心血管功能产生了负面影响，包括增加：（a）两种行为应激源中的抑郁相关行为，（B）基础平均动脉压和心率，以及（c）对行为应激源的心血管反应性。这些结果表明，一只动物的催产素和社会行为的中断可能会在未经治疗的社会伙伴中产生社会压力的指标。这一初步研究为未来研究人类对社会经验的反应机制奠定了基础。
Negative social experiences may influence psychological and physiological health via altered central oxytocin communication. The prairie vole is valuable for investigating the potential influence of oxytocin on responses to social experiences. Prairie voles are socially monogamous, live in pairs or family groups, and respond negatively to changes in the social environment. This study investigated the hypothesis that disruptions of oxytocin in one prairie vole of a cohabitating male-female pair would alter social behavior in that specific animal; and these behavioral changes in turn would influence the untreated partner?s behavior and physiology. Pharmacological antagonism of oxytocin with the receptor antagonist L-368,899 in the male prairie vole disrupted social behaviors between the male and his untreated female partner. This manipulation also negatively influenced the behavior and cardiovascular function in the untreated female partner, including increased: (a) depression-relevant behaviors in two behavioral stressors, (b) basal mean arterial pressure and heart rate, and (c) cardiovascular reactivity to the behavioral stressors. These results suggest that disruptions of oxytocin and social behavior in one animal may produce indicators of social stress in an untreated social partner. This preliminary research provides a foundation for future studies to investigate mechanisms underlying responses to social experiences in humans.