Melohenryines A and B, two new indole alkaloids from Melodinus henryi
Melohenryines A and B, two new indole alkaloids from Melodinus henryi
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Melohenryines A 和 B，两种来自 Melodinus henryi 的新吲哚生物碱
DOI：
10.1016/j.phytol.2017.07.001
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发表时间：
2017-09-01
影响因子：
1.7
通讯作者：
Hao, Xiao-Jiang
中科院分区：
文献类型：
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作者：
Guo, Ling-Li;Yuan, Yu-Xi;Hao, Xiao-Jiang
从川楝（Melodinus henryi）的枝叶中分得两个新的单萜吲哚生物碱，即川楝素A和B（1和2），沿着六个已知的吲哚生物碱。新生物碱的结构通过广泛的光谱技术包括NMR光谱和质谱确定。Melohenryine A（1）代表在C-19位具有酯羰基的单萜吲哚生物碱的第一个实例。所有的新化合物进行了评价，在体外细胞毒性对几种人类癌细胞系。
Two new monoterpenoid indole alkaloids, melohenryines A and B (1 and 2), along with six known indole alkaloids, were isolated from the twigs and leaves of Melodinus henryi. Structures of the new alkaloids were established by extensive spectroscopic techniques including NMR spectroscopy and mass spectrometry. Melohenryine A (1) represents the first example of monoterpenoid indole alkaloids characterized an ester carbonyl group at C-19 position. All of the new compounds were evaluated for in vitro cytotoxicity against several human cancer cell lines.