Migration of cells in a social context
Migration of cells in a social context
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DOI：
10.1073/pnas.1204291110
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发表时间：
2013-01-02
影响因子：
11.1
通讯作者：
Quake, Stephen R.
中科院分区：
文献类型：
--
作者：
Vedel, Soren;Tay, Savas;Quake, Stephen R.
在多细胞生物和复杂的生态系统中，细胞在社会背景下迁移。虽然这对生命的基本过程至关重要，但对邻近细胞对个体的影响仍然知之甚少。先前对分离细胞的研究已经观察到了一种典型的迁移行为，其特征是短时间的定向持续性和长时间的随机运动。我们在社会背景下发现了更丰富的动态，方向性，位移和速度都有显着变化，这些都是由局部细胞密度调制的。我们开发了一个数学模型的基础上，实验确定的“细胞交通规则”和基本的物理，揭示了这些新兴的行为是由单细胞特性和细胞间的相互作用，后者被占主导地位的伪足形成偏介导的分泌化学物质和伪足崩溃后碰撞。该模型展示了复杂生物学的各个方面如何通过简单的物理规则来解释，并为未来研究单个细胞的集体迁移提供了快速测试平台。
In multicellular organisms and complex ecosystems, cells migrate in a social context. Whereas this is essential for the basic processes of life, the influence of neighboring cells on the individual remains poorly understood. Previous work on isolated cells has observed a stereotypical migratory behavior characterizedby short-timedirectional persistence with long-time random movement. We discovered a much richer dynamic in the social context, with significant variations in directionality, displacement, and speed, which are all modulated by local cell density. We developed a mathematical model based on the experimentally identified "cellular traffic rules" and basic physics that revealed that these emergent behaviors are caused by the interplay of single-cell properties and intercellular interactions, the latter being dominated by a pseudopod formation bias mediated by secreted chemicals and pseudopod collapse following collisions. The model demonstrates how aspects of complex biology can be explained by simple rules of physics and constitutes a rapid test bed for future studies of collective migration of individual cells.