iPOP goes the world: integrated personalized Omics profiling and the road toward improved health care.
iPOP goes the world: integrated personalized Omics profiling and the road toward improved health care.
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DOI：
10.1016/j.chembiol.2013.05.001
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发表时间：
2013-05-23
影响因子：
--
通讯作者：
Snyder M
中科院分区：
文献类型：
--
作者：
Li-Pook-Than J;Snyder M
一个人的健康取决于他们的DNA以及环境因素（环境或暴露）。预计尽管基因组是个体的蓝图，但其与其他基因组（如DNA甲基组、转录组、蛋白质组以及代谢组）的分析将进一步提供对个体生理和健康状况的动态评估。这篇综述将有助于分类组学分析的最新进展，以及如何将组学整合用于医学研究。我们相信，综合个人组学分析（iPOP）是通往个性化医疗保健新道路的敲门砖，可以改善1)疾病风险评估，2)诊断准确性，3)疾病监测，4)靶向治疗和5)了解疾病状态的生物学过程以预防疾病。
The health of an individual depends upon their DNA as well as environmental factors (environome or exposome). It is expected that although the genome is the blueprint of an individual, its analysis with that of the other omes, such as the DNA methylome, the transcriptome, proteome, as well as metabolome will further provide a dynamic assessment of the physiology and health state of an individual. This review will help to categorize the current progress of omics analyses, and how omics integration can be used for medical research. We believe that integrative Personal Omics Profiling (iPOP) is a stepping stone to a new road to personalized health care and may improve 1) Disease risk assessment, 2) Accuracy of diagnosis, 3) Disease monitoring, 4) Targeted treatments and 5) Understanding the biological processes of disease states for their prevention.
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影响因子：
7
作者：
Boyle AP;Hong EL;Hariharan M;Cheng Y;Schaub MA;Kasowski M;Karczewski KJ;Park J;Hitz BC;Weng S;Cherry JM;Snyder M
通讯作者：
Snyder M
影响因子：
64.8
作者：
CRICK, F
通讯作者：
CRICK, F
影响因子：
9.2
作者：
McDonald D;Clemente JC;Kuczynski J;Rideout JR;Stombaugh J;Wendel D;Wilke A;Huse S;Hufnagle J;Meyer F;Knight R;Caporaso JG
通讯作者：
Caporaso JG
影响因子：
168.9
作者：
Ashley, Euan A.;Butte, Atul J.;Wheeler, Matthew T.;Chen, Rong;Klein, Teri E.;Dewey, Frederick E.;Dudley, Joel T.;Ormond, Kelly E.;Pavlovic, Aleksandra;Morgan, Alexander A.;Pushkarev, Dmitry;Neff, Norma F.;Hudgins, Louanne;Gong, Li;Hodges, Laura M.;Berlin, Dorit S.;Thorn, Caroline F.;Sangkuhl, Katrin;Hebert, Joan M.;Woon, Mark;Sagreiya, Hersh;Whaley, Ryan;Knowles, Joshua W.;Chou, Michael F.;Thakuria, Joseph V.;Rosenbaum, Abraham M.;Zaranek, Alexander Wait;Church, George M.;Greely, Henry T.;Quake, Stephen R.;Altman, Russ B.
通讯作者：
Altman, Russ B.
影响因子：
64.8
作者：
Bell, D.;Berchuck, A.;Birrer, M.;Chien, J.;Cramer, D. W.;Dao, F.;Dhir, R.;DiSaia, P.;Gabra, H.;Glenn, P.;Godwin, A. K.;Gross, J.;Hartmann, L.;Huang, M.;Huntsman, D. G.;Iacocca, M.;Imielinski, M.;Kalloger, S.;Karlan, B. Y.;Levine, D. A.;Mills, G. B.;Morrison, C.;Mutch, D.;Olvera, N.;Orsulic, S.;Park, K.;Petrelli, N.;Rabeno, B.;Rader, J. S.;Sikic, B. I.;Smith-McCune, K.;Sood, A. K.;Bowtell, D.;Penny, R.;Testa, J. R.;Chang, K.;Dinh, H. H.;Drummond, J. A.;Fowler, G.;Gunaratne, P.;Hawes, A. C.;Kovar, C. L.;Lewis, L. R.;Morgan, M. B.;Newsham, I. F.;Santibanez, J.;Reid, J. G.;Trevino, L. R.;Wu, Y. -Q.;Wang, M.;Muzny, D. M.;Wheeler, D. A.;Gibbs, R. A.;Getz, G.;Lawrence, M. S.;Cibulskis, K.;Sivachenko, A. Y.;Sougnez, C.;Voet, D.;Wilkinson, J.;Bloom, T.;Ardlie, K.;Fennell, T.;Baldwin, J.;Gabriel, S.;Lander, E. S.;Ding, L.;Fulton, R. S.;Koboldt, D. C.;McLellan, M. D.;Wylie, T.;Walker, J.;O'Laughlin, M.;Dooling, D. J.;Fulton, L.;Abbott, R.;Dees, N. D.;Zhang, Q.;Kandoth, C.;Wendl, M.;Schierding, W.;Shen, D.;Harris, C. C.;Schmidt, H.;Kalicki, J.;Delehaunty, K. D.;Fronick, C. C.;Demeter, R.;Cook, L.;Wallis, J. W.;Lin, L.;Magrini, V. J.;Hodges, J. S.;Eldred, J. M.;Smith, S. M.;Pohl, C. S.;Vandin, F.;Raphael, B. J.;Weinstock, G. M.;Mardis, R.;Wilson, R. K.;Meyerson, M.;Winckler, W.;Getz, G.;Verhaak, R. G. W.;Carter, S. L.;Mermel, C. H.;Saksena, G.;Nguyen, H.;Onofrio, R. C.;Lawrence, M. S.;Hubbard, D.;Gupta, S.;Crenshaw, A.;Ramos, A. H.;Ardlie, K.;Chin, L.;Protopopov, A.;Zhang, Juinhua;Kim, T. M.;Perna, I.;Xiao, Y.;Zhang, H.;Ren, G.;Sathiamoorthy, N.;Park, R. W.;Lee, E.;Park, P. J.;Kucherlapati, R.;Absher, D. M.;Waite, L.;Sherlock, G.;Brooks, J. D.;Li, J. Z.;Xu, J.;Myers, R. M.;Laird, P. W.;Cope, L.;Herman, J. G.;Shen, H.;Weisenberger, D. J.;Noushmehr, H.;Pan, F.;Triche, T., Jr.;Berman, B. P.;Van den Berg, D. J.;Buckley, J.;Baylin, S. B.;Spellman, P. T.;Purdom, E.;Neuvial, P.;Bengtsson, H.;Jakkula, L. R.;Durinck, S.;Han, J.;Dorton, S.;Marr, H.;Choi, Y. G.;Wang, V.;Wang, N. J.;Ngai, J.;Conboy, J. G.;Parvin, B.;Feiler, H. S.;Speed, T. P.;Gray, J. W.;Levine, D. A.;Socci, N. D.;Liang, Y.;Taylor, B. S.;Schultz, N.;Borsu, L.;Lash, A. E.;Brennan, C.;Viale, A.;Sander, C.;Ladanyi, M.;Hoadley, K. A.;Meng, S.;Du, Y.;Shi, Y.;Li, L.;Turman, Y. J.;Zang, D.;Helms, E. B.;Balu, S.;Zhou, X.;Wu, J.;Topal, M. D.;Hayes, D. N.;Perou, C. M.;Getz, G.;Voet, D.;Saksena, G.;Zhang, Junihua;Zhang, H.;Wu, C. J.;Shukla, S.;Cibulskis, K.;Lawrence, M. S.;Sivachenko, A.;Jing, R.;Park, R. W.;Liu, Y.;Park, P. J.;Noble, M.;Chin, L.;Carter, H.;Kim, D.;Karchin, R.;Spellman, P. T.;Purdom, E.;Neuvial, P.;Bengtsson, H.;Durinck, S.;Han, J.;Korkola, J. E.;Heiser, L. M.;Cho, R. J.;Hu, Z.;Parvin, B.;Speed, T. P.;Gray, J. W.;Schultz, N.;Cerami, E.;Taylor, B. S.;Olshen, A.;Reva, B.;Antipin, Y.;Shen, R.;Mankoo, P.;Sheridan, R.;Ciriello, G.;Chang, W. K.;Bernanke, J. A.;Borsu, L.;Levine, D. A.;Ladanyi, M.;Sander, C.;Haussler, D.;Benz, C. C.;Stuart, J. M.;Benz, S. C.;Sanborn, J. Z.;Vaske, C. J.;Zhu, J.;Szeto, C.;Scott, G. K.;Yau, C.;Hoadley, K. A.;Du, Y.;Balu, S.;Hayes, D. N.;Perou, C. M.;Wilkerson, M. D.;Zhang, N.;Akbani, R.;Baggerly, K. A.;Yung, W. K.;Mills, G. B.;Weinstein, J. N.;Penny, R.;Shelton, T.;Grimm, D.;Hatfield, M.;Morris, S.;Yena, P.;Rhodes, P.;Sherman, M.;Paulauskis, J.;Millis, S.;Kahn, A.;Greene, J. M.;Sfeir, R.;Jensen, M. A.;Chen, J.;Whitmore, J.;Alonso, S.;Jordan, J.;Chu, A.;Zhang, Jinghui;Barker, A.;Compton, C.;Eley, G.;Ferguson, M.;Fielding, P.;Gerhard, D. S.;Myles, R.;Schaefer, C.;Shaw, K. R. Mills;Vaught, J.;Vockley, J. B.;Good, P. J.;Guyer, M. S.;Ozenberger, B.;Peterson, J.;Thomson, E.
通讯作者：
Thomson, E.