Dissecting affinity maturation: a model explaining selection of antibody-forming cells and memory B cells in the germinal centre
Dissecting affinity maturation: a model explaining selection of antibody-forming cells and memory B cells in the germinal centre
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DOI：
10.1016/s0167-5699(00)01687-x
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发表时间：
2000-09-01
期刊：
影响因子：
--
通讯作者：
Smith, KGC
中科院分区：
文献类型：
--
作者：
Tarlinton, DM;Smith, KGC
直到最近，细胞凋亡、生发中心(GC)的选择和高亲和力抗体形成细胞(AFC)和记忆B细胞的产生之间的关系还不清楚。在这里，塔林顿和史密斯提出了一个模型，解释了GC产生从高亲和力AFCs到Memory B细胞的转换，并解释了凋亡抑制因子Bcl2如何影响记忆细胞，但不影响骨髓AFCs。
Until recently, the relationship between apoptosis, selection in the germinal centre (GC) and production of high-affinity antibody-forming cells (AFCs) and memory B cells has been unclear. Here, Tarlinton and Smith present a model that accounts for the switch in GC production from high-affinity AFCs to memory B cells, and explain how Bcl-2, an inhibitor of apoptosis, can influence memory cells but not bone marrow AFCs.