Caging and Uncaging Genetics.
Caging and Uncaging Genetics.
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DOI：
10.1371/journal.pbio.1002525
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发表时间：
2016-07
期刊：
影响因子：
9.8
通讯作者：
Colegrave N
中科院分区：
文献类型：
--
作者：
Little TJ;Colegrave N
对于生物学来说，重要的是要了解在高度简化的实验室环境中进行的观察是否可以推广到遗传变异被分类以产生适应的恶劣和嘈杂的自然环境。但是，通过在实验室里研究一个反映野生环境的遗传多样性种群，我们能学到什么呢？研究遗传变异的最佳设计是什么？我们什么时候才应该考虑呢？正确的实验方法取决于你想知道什么。对单一基因型的实验是有力的和适当的。对多种基因型的实验是有力的和适当的。正确的实验设计取决于所问的问题。
It is important for biology to understand if observations made in highly reductionist laboratory settings generalise to harsh and noisy natural environments in which genetic variation is sorted to produce adaptation. But what do we learn by studying, in the laboratory, a genetically diverse population that mirrors the wild? What is the best design for studying genetic variation? When should we consider it at all? The right experimental approach depends on what you want to know. Experiments on a single genotype are powerful and appropriate. Experiments on multiple genotypes are powerful and appropriate. The right experimental design depends on the question being asked.