The Challenges of Validating Diagnostic Methods and Selecting Appropriate Gold Standards
The Challenges of Validating Diagnostic Methods and Selecting Appropriate Gold Standards
复制标题
验证诊断方法和选择适当的黄金标准的挑战
DOI：
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
Christopher Longbottom
中科院分区：
文献类型：
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作者：
M. Huysmans;Christopher Longbottom
龋病诊断方法通常是龋病病变检测和测量的方法。龋齿病变发生在组织损伤的连续尺度上，从亚临床表面变化到到达牙髓的宏观空洞。病变在这种连续尺度上的任何变化都为诊断疾病活动或缓解提供了机会。针对再矿化剂的研究可能集中在易于再矿化的病变上，并选择一种方法来测量早期病变的微小变化。一般的龋齿管理策略取决于检测病变发展的所有阶段，并且优选覆盖早期到晚期阶段的方法。本文讨论了验证龋齿诊断方法的一些方法学问题。现有的金标准龋齿病变进行了讨论，其适用于不同的应用程序，其“有效性”，因为它是已知的或可以推断。金标准进行比较，就其测量病变参数和再现性而言。初步的结论，制定和建议，为今后的研究。
Caries diagnostic methods are usually methods for caries lesion detection and measurement. Caries lesions occur on a continuous scale of tissue damage, from subclinical surface changes to macroscopic cavities reaching the pulp. Any change of a lesion on this continuous scale offers the opportunity for the diagnosis of disease activity or remission. Research aimed at remineralizing agents may focus on lesions that are amenable to remineralization, and select a method that will measure small changes in early lesions. General caries management strategies depend on detecting all stages of lesion development, and methods covering early to late stages are preferred. This paper addresses some methodological issues in validating caries diagnostic methods. The available gold standards for caries lesions are discussed, with their suitability in different applications, and their “validity” as far as it is known or can be inferred. The gold standards are compared as far as their measurement of lesion parameters and reproducibility is concerned. Tentative conclusions are formulated, and recommendations for future research are given.
DOI：
10.1111/j.1600-0714.1985.tb00538.x
发表时间：
1985-09
期刊：
Journal of oral pathology
影响因子：
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作者：
J. Wefel;B. Clarkson;J. R. Heilman
通讯作者：
J. Wefel;B. Clarkson;J. R. Heilman