Effect of long-term administration of antidepressant treatments on serotonin release in brain regions involved in obsessive-compulsive disorder
Effect of long-term administration of antidepressant treatments on serotonin release in brain regions involved in obsessive-compulsive disorder
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DOI：
10.1016/s0006-3223(98)00154-1
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发表时间：
1999-01-15
影响因子：
10.6
通讯作者：
Blier, P
中科院分区：
文献类型：
--
作者：
Bergqvist, PBF;Bouchard, C;Blier, P
背景：在包括电休克（ECS）疗法和单胺氧化酶抑制剂（MAOIs）在内的所有抗抑郁药物治疗中，只有选择性5-羟色胺（5-HT）再摄取抑制剂（SSRIs）对强迫症（OCD）有明确的治疗效果。用SSRI类帕罗西汀治疗8周，而不是3周，结果是电诱发[H-3]5-羟色胺释放增加，并导致豚鼠眶额皮质（与强迫症有关的大脑区域）5-羟色胺自身受体脱敏。方法：在本研究中，研究了SSRI氟西汀、ECS和可逆性A型MAOI莫氯贝胺长期治疗对下丘脑、扣带皮层和眶额皮层制备的预载豚鼠脑片诱发的[H-3]5-HT释放的影响。结果：氟西汀治疗在三个脑区增强了[H-3]5-HT释放，但仅在下丘脑和眶额皮层使5-HT自身受体脱敏。ECS治疗没有导致任何脑区电诱发的[H-3]5-HT释放或5-HT自身受体敏感性的改变。莫氯贝胺仅增加眼窝额叶皮层[H-3]5-HT的释放，而不改变5-HT自身受体的敏感性。结论：这些发现表明，只有对强迫症有效的治疗才能使眼窝额叶皮层末端5-HT自身受体脱敏。(C) 1999年生物精神病学学会。
Background: Among all antidepressant treatments, including electroconvulsive shock (ECS) therapy and monoamine oxidase inhibitors (MAOIs), only the selective serotonin (5-HT) reuptake inhibitors (SSRIs) exert a clear therapeutic effect in obsessive-compulsive disorder (OCD). An 8-week, but not a 3-week treatment with the SSRI paroxetine results in an increased electrically Evoked [H-3]5-HT release and a desensitization of 5-HT autoreceptors in the guinea pig orbitofrontal cortex a brain region implicated in OCD.Methods: In the present study, the effect of long-term treatment with the SSRI fluoxetine, ECS, and the reversible type A MAOI moclobemide was investigated on evoked [H-3]5-HT release from preloaded guinea pig brain slices prepared from the hypothalamus, cingulate cortex, and orbitofrontal cortexResults: Fluoxetine treatment yielded an enhanced [H-3]5-HT release in the three brain areas, but a desensitization of the 5-HT autoreceptor only in the hypothalamus and orbitofrontal cortex. ECS treatment did not result in any alteration of the electrically evoked [H-3]5-HT release or of 5-HT autoreceptor sensitivity in any of the brain regions. Moclobemide increased [H-3]5-HT release only in the orbitofrontal cortex without any alteration in the 5-HT autoreceptor sensitivity.Conclusions: These findings indicate that only treatments effective in OCD have the capacity to desensitize the terminal 5-HT autoreceptor in the orbitofrontal cortex. (C) 1999 Society of Biological Psychiatry.