Medial septum differentially regulates dopamine neuron activity in the rat ventral tegmental area and substantia nigra via distinct pathways
Medial septum differentially regulates dopamine neuron activity in the rat ventral tegmental area and substantia nigra via distinct pathways
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DOI：
10.1038/s41386-018-0048-2
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发表时间：
2018-09-01
影响因子：
7.6
通讯作者：
Grace, Anthony A.
中科院分区：
文献类型：
--
作者：
Bortz, David M.;Grace, Anthony A.
内侧隔（MS）影响海马活动，而海马反过来又调节中脑多巴胺（DA）神经元活动。然而，MS激活如何影响中脑DA活性仍有待确定。通过将NMDA（0.75 μ g/0.2 μ L）注入麻醉的雄性Sprague-Dawley大鼠的内侧隔中并记录腹侧被盖区（VTA）和黑质背侧部（SNc）中的多巴胺神经元活性来解决这个问题。MS激活使腹侧被盖区自发活动的DA能神经元数量增加（71%），使黑质腹侧被盖区自发活动的DA能神经元数量减少（40%）。在VTA和SNc的影响需要腹侧下托，但差异依赖于胆碱能和GABA能的机制内的vSub和吻侧和尾侧的腹侧苍白球，分别。MS激活也减少安非他明诱导的运动行为，这是依赖于GABA能输入海马。这些研究结果表明，MS差异调节中纹状体DA传输通过不同的途径。
The medial septum (MS) impacts hippocampal activity and the hippocampus, in turn, regulates midbrain dopamine (DA) neuron activity. However, it remains to be determined how MS activation impacts midbrain DA activity. This question was addressed by infusing NMDA (0.75 mu g/0.2 mu L) into the medial septum of anesthetized male Sprague-Dawley rats and recording dopamine neuron activity in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc). MS activation increased (71%) the number of spontaneously active DA neurons in the VTA, and decreased (40%) the number of active DA neurons in the SNc. Effects in both the VTA and SNc required the ventral subiculum, but were differentially dependent on cholinergic and GABAergic mechanisms within the vSub and rostral and caudal subregions of the ventral pallidum, respectively. MS activation also decreased amphetamine-induced locomotor behavior, which was dependent on GABAergic inputs to the hippocampus. These findings demonstrate that the MS differentially regulates meso-striatal DA transmission via distinct pathways.