Time course of neural activity correlated with colored-hearing synesthesia
Time course of neural activity correlated with colored-hearing synesthesia
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DOI：
10.1093/cercor/bhm072
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发表时间：
2008-02-01
期刊：
影响因子：
3.7
通讯作者：
Jaencke, Lutz
中科院分区：
文献类型：
--
作者：
Beeli, Gian;Esslen, Michaela;Jaencke, Lutz
联觉被定义为以两种或多种感觉方式（即跨方式联动）对刺激的不自觉和自动感知。彩色听觉联觉者在听到音调或言语时会感受到颜色。基于事件相关电位，我们在听觉语言刺激期间的彩色听觉联觉和非联觉控制中采用了具有高时间分辨率的脑电断层扫描。联觉者和对照组在 N1 和 P2 分量上对单词和字母的听觉诱发电位有所不同，显示联觉者的潜伏期较长，振幅较低。通过低分辨率脑电磁断层扫描对这些成分的脑内来源进行了估计，结果显示左后颞下区域、梭状回（V4）的颜色区域内和眶额脑区域（腹内侧和外侧）的联觉有更强的激活。差异早在刺激开始后 122 毫秒就出现了。我们的研究结果复制并扩展了早期关于彩色听觉联觉的功能磁共振成像和正电子发射断层扫描的报告，并提供了有关联觉时间过程的新信息，证明了这种不寻常和显着现象的快速且可能自动处理。
Synesthesia is defined as the involuntary and automatic perception of a stimulus in 2 or more sensory modalities (i.e., cross-modal linkage). Colored-hearing synesthetes experience colors when hearing tones or spoken utterances. Based on event-related potentials we employed electric brain tomography with high temporal resolution in colored-hearing synesthetes and nonsynesthetic controls during auditory verbal stimulation. The auditory-evoked potentials to words and letters were different between synesthetes and controls at the N1 and P2 components, showing longer latencies and lower amplitudes in synesthetes. The intracerebral sources of these components were estimated with low-resolution brain electromagnetic tomography and revealed stronger activation in synesthetes in left posterior inferior temporal regions, within the color area in the fusiform gyrus (V4), and in orbitofrontal brain regions (ventromedial and lateral). The differences occurred as early as 122 ms after stimulus onset. Our findings replicate and extend earlier reports with functional magnetic resonance imaging and positron emission tomography in colored-hearing synesthesia and contribute new information on the time course in synesthesia demonstrating the fast and possibly automatic processing of this unusual and remarkable phenomenon.