Hepatitis B virus surface antigen in glomerular immune complex deposits of patients with systemic lupus erythematosus
Hepatitis B virus surface antigen in glomerular immune complex deposits of patients with systemic lupus erythematosus
复制标题
DOI：
10.1111/j.1365-2559.1982.tb02711.x
复制
发表时间：
1982-03
期刊：
影响因子：
6.4
通讯作者：
L. Looi;K. Prathap
中科院分区：
文献类型：
--
作者：
L. Looi;K. Prathap
In view of a high prevalence of hepatitis B virus infection in the Malaysian population, indirect immunofluorescence examination for hepatitis B surface antigen (HBsAg) was routinely performed on renal biopsy specimens at the University Hospital, Kuala Lumpur, over a 3‐year period. Examination of renal tissue from 259 patients, including 47 with systemic lupus erythematosus (SLE), revealed 43 cases with HBsAg in glomerular immune complexes. A significantly high proportion (30/43) of these were SLE patients. The deposits were granular in nature, situated in both the capiliary walls and mesangium and associated with immunoglobulin deposition. Morphological patterns of lupus nephritis involved were focal pro‐liferative (one case), diffuse proliferative (23 cases) and membranous (six cases). None of these patients showed clinical evidence of liver disease. The significance of these findings remains uncertain, but the possibility exists that the hepatitis B virus may have a role in the pathogenesis of SLE in the tropics where both SLE and HBs antigenaemia are common.
