Polybrominated Diphenyl Ethers (PBDEs) in Breast Milk and Neuropsychological Development in Infants
Polybrominated Diphenyl Ethers (PBDEs) in Breast Milk and Neuropsychological Development in Infants
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DOI：
10.1289/ehp.1205266
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发表时间：
2012-12-01
影响因子：
10.4
通讯作者：
Vrijheid, Martine
中科院分区：
文献类型：
--
作者：
Gascon, Mireia;Fort, Marta;Vrijheid, Martine
背景技术背景：多溴联苯醚（PBDEs）对儿童神经心理发育的潜在影响越来越引起人们的兴趣，但只有少数小型研究评估了这种影响。结论：我们的目标是检查初乳中PBDE浓度与婴儿神经心理发育之间的关系，并评估其他持久性有机污染物（POP）对这种关系的影响。我们测量了在西班牙出生队列招募的290名妇女的初乳样本中多溴联苯醚和其他持久性有机污染物的浓度。我们在12-18个月大时用贝利婴儿发展量表测试儿童的智力和心理发展。我们分析了七个最常见的多溴二苯醚同系物（溴二苯醚47，99，100，153，154，183，209）和每一个同系物的总和independent.RESULTS：增加西格玛7 PBDEs浓度显示了边缘统计学意义的相关性与智力发育评分下降（每对数纳克/IG脂β = -2.25，95% CI：4.75，0.26）。浓度最高的同系物BDE-209似乎是造成这种关联的主要同系物（β =-2.40，95%置信区间：-4.79，-0.01）。几乎没有证据表明它与精神发育有关。在对其他持久性有机污染物进行调整后，BDE-209与智力发育评分之间的关联性变得稍弱（β =-2.10，95%CI：-4.66，0.46）。结论：我们的研究结果表明，初乳中多溴二苯醚浓度的增加与婴儿智力发育不良之间存在关联，特别是BDE-209，但需要在更大规模的研究中予以证实。如果存在因果关系，这种关联可能是由于BDE-209的代谢物（包括羟基化多溴二苯醚）未经测量所致，与BDE-209相比，羟基化多溴二苯醚毒性更强、更稳定、更容易穿过胎盘并到达大脑。
BACKGROUND: There is increasing interest in the potential effects of polybrominated diphenyl ethers (PBDEs) on children's neuropsychological development, but only a few small studies have evaluated such effects.OBJECTIVES: Our goal was to examine the association between PBDE concentrations in colostrum and infant neuropsychological development and to assess the influence of other persistent organic pollutants (POPs) on such association.METHODS: We measured concentrations of PBDEs and other POPs in colostrum samples of 290 women recruited in a Spanish birth cohort. We tested children for mental and psychomotor development with the Bayley Scales of Infant Development at 12-18 months of age. We analyzed the sum of the seven most common PBDE congeners (BDEs 47, 99, 100, 153, 154, 183, 209) and each congener separately.RESULTS: Increasing Sigma 7PBDEs concentrations showed an association of borderline statistical significance with decreasing mental development scores (beta per log ng/ig lipid = -2.25; 95% CI: 4.75, 0.26). BDE-209, the congener present in highest concentrations, appeared to be the main congener responsible for this association (beta = -2.40, 95% CI: -4.79, -0.01). There was little evidence for an association with psychomotor development. After adjustment for other POPs, the BDE-209 association with mental development score became slightly weaker (beta = -2.10, 95% CI: -4.66, 0.46).CONCLUSIONS: Our findings suggest an association between increasing PBDE concentrations in colostrum and a worse infant mental development, particularly for BDE-209, but require confirmation in larger studies. The association, if causal, may be due to unmeasured BDE-209 metabolites, including OH-PBDEs (hydroxylated PBDEs), which are more toxic, more stable, and more likely to cross the placenta and to easily reach the brain than BDE-209.