Poor Physical Performance and Dementia in the Oldest Old The 90+ Study
Poor Physical Performance and Dementia in the Oldest Old The 90+ Study
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DOI：
10.1001/jamaneurol.2013.583
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发表时间：
2013-01-01
期刊：
影响因子：
29
通讯作者：
Kawas, Claudia H.
中科院分区：
文献类型：
--
作者：
Bullain, Szofia S.;Corrada, Maria M.;Kawas, Claudia H.
目的：研究高龄老人身体活动能力与痴呆之间的横向关系，设计：横断面研究。设置：90+研究是一项基于人群的、纵向的、关于衰老和痴呆的流行病学研究，于2003年1月1日至2009年11月30日在加州大学欧文分校进行。参与者：共有629名来自90+研究的参与者被纳入研究。平均年龄为94岁，大多数（72.5%）是women.Main结果测量：全因痴呆，根据诊断和统计手册的精神疾病（第四版）的标准，是主要的结果测量。自变量是身体表现指标，包括4米步行、5个椅子站立、站立平衡和握力，每个指标的评分为0 - 4分（0分，不能执行; 4分，最佳表现）。在调整年龄和性别后，通过Logistic回归估计与身体表现措施有关的痴呆症的几率。结果：所有措施中身体表现不佳与痴呆症的几率增加显著相关（P < .001）。每一个单位的优势比下降的体能评分为2.1 4米走，2.1椅子的立场，1.9站立平衡，1.7握力strength.Conclusions：我们发现了一个强大的横截面之间的关系较差的体能和痴呆症的人90岁及以上。我们的研究结果表明，痴呆症是一个复杂的神经退行性过程，可能会影响身体表现和认知。需要进一步的研究来确定身体表现差和认知功能障碍之间的时间关系。美国医学会神经学杂志2013;70（1）：107-113。2012年10月22日在线发布。doi：10.1001/jamaneurol.2013.583
Objective: To examine the cross-sectional relationship between physical performance and dementia in the oldest old (those >= 90 years of age).Design: Cross-sectional study.Setting: The 90+ Study is a population-based, longitudinal, epidemiologic study of aging and dementia performed at the University of California, Irvine, from January 1, 2003, through November 30, 2009.Participants: A total of 629 participants from The 90+ Study were included in the study. The mean age was 94 years, and most (72.5%) were women.Main Outcome Measures: All-cause dementia, based on Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) criteria, was the main outcome measure. The independent variables were physical performance measures, including 4-m walk, 5 chair stands, standing balance, and grip strength, each scored from 0 to 4 (0, unable to perform; 4, best performance). Odds of dementia in relation to the physical performance measures were estimated by logistic regression after adjustment for age and sex.Results: Poor physical performance in all measures was significantly associated with increased odds of dementia (P < .001). Odds ratios for every unit decrease in physical performance score were 2.1 for 4-m walk, 2.1 for chair stands, 1.9 for standing balance, and 1.7 for grip strength.Conclusions: We found a strong cross-sectional relationship between poor physical performance and dementia in people 90 years and older. Our findings suggest that dementia is a complex neurodegenerative process that may affect physical performance and cognition. Additional research is necessary to determine the temporal relationship between poor physical performance and cognitive dysfunction. JAMA Neurol. 2013;70(1):107-113. Published online October 22, 2012. doi:10.1001/jamaneurol.2013.583