MAGNETIZATION-TRANSFER IMAGING OF LUMBAR DISC DEGENERATION - CORRELATION OF RELAXATION PARAMETERS WITH BIOCHEMISTRY
MAGNETIZATION-TRANSFER IMAGING OF LUMBAR DISC DEGENERATION - CORRELATION OF RELAXATION PARAMETERS WITH BIOCHEMISTRY
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DOI：
10.1097/00007632-199412150-00018
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发表时间：
1994-12-15
期刊：
影响因子：
3
通讯作者：
HAAPASALO, H
中科院分区：
文献类型：
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作者：
PAAJANEN, H;KOMU, M;HAAPASALO, H
目标.作者试图找出磁化传递（MT）成像与磁共振成像（MRI）是否能提供椎间盘退变的新信息。磁化转移技术提高了软组织的对比度和表征。它测量组织中自由和大分子结合水质子之间的交叉弛豫和化学交换过程。在0.1T下对4例活体和6例尸体脊柱进行了腰椎MRI和MT检查。椎间盘水、蛋白质、蛋白多糖和胶原含量与MT参数相关。在退化的椎间盘中，自由水质子和大分子结合质子之间的磁化转移速率升高。椎间盘胶原蛋白和总蛋白浓度与转移率呈正相关。正常和退变椎间盘在MT图像上的对比度变化不大。需要更多的研究来充分确定MT过程在椎间盘中的重要性。
Objectives. The authors attempted to find out if magnetization transfer (MT) imaging with magnetic-resonance imaging (MRI) provides new information of disc degeneration.Summary of Background Data. Magnetization transfer technique improves soft-tissue contrast and characterization. It measures the cross-relaxation and chemical exchange processes between free and macromolecule-bound water protons in tissues.Methods. The lumbar MRI and MT of four living subjects and six cadaveric spines were performed at 0.1 T. Disc water, protein, proteoglycan, and collagen contents of cadaveric samples were correlated to MT parameters.Results. The rate of magnetization transfer between free-water protons and the macromolecule-bound protons was elevated in degenerated discs. A positive correlation was found between disc collagen and total protein concentration and the rate of transfer. The contrast of normal and degenerated discs on MT images was not altered much.Conclusions. More studies are needed to fully establish the importance of MT processes in the disc.