Motor activity during asymptomatic nocturnal hypoglycemia in adolescents with type 1 diabetes mellitus
Motor activity during asymptomatic nocturnal hypoglycemia in adolescents with type 1 diabetes mellitus
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DOI：
10.1007/s00592-004-0141-3
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发表时间：
2004-06-01
影响因子：
3.8
通讯作者：
Battelino, T
中科院分区：
文献类型：
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作者：
Radan, I;Rajer, E;Battelino, T
据报道，13%-56% 的 1 型糖尿病青少年患有夜间低血糖。超过50%的患者可能无症状。迄今为止，还没有成功检测无症状夜间低血糖 (ANH) 的无创方法。本研究的目的是通过体动记录仪评估 1 型糖尿病青少年 ANH 发作期间运动活动的定量变化。共有 18 名有 ANH 病史的 10-16 岁患者接受了调查。 22.30 至 06.00 之间，用微型泵每半小时采样一次血样，并将活动记录仪固定在右手腕上。测量血糖浓度并与运动活动进行比较。 10名患者（55%）出现夜间低血糖，低血糖期间血糖为3.00+/-0.17 mmol/l（范围为1.2-3.4 mmol/l），低血糖持续时间为1.95+/-1.34小时（范围为0.5-5.0小时）。所有低血糖时期均无临床症状。回归分析显示血糖浓度与各自的 30 分钟活动计数之间存在统计显着的线性相关性 (p=0.03)。夜间低血糖患者的活动计数显着（方差分析，p
Nocturnal hypoglycemia is reported in 13%-56% of adolescents with type 1 diabetes mellitus. It may be asymptomatic in more than 50% of patients. No noninvasive method for detecting asymptomatic nocturnal hypoglycemia (ANH) has so far proven successful. The aim of the present study was to evaluate quantitative changes of motor activity by actigraphy during episodes of ANH in adolescents with type 1 diabetes mellitus. A total of 18 patients aged 10-16 years with a history of ANH were investigated. Blood was sampled at half-hourly intervals between 22.30 and 06.00 hours with a micropump, and an actigraph was fastened to the right wrist. Blood glucose concentrations were measured and compared to motor activity. Nocturnal hypoglycemia was recorded in 10 patients (55%), with blood glucose during periods of hypoglycemia of 3.00+/-0.17 mmol/l (range, 1.2-3.4 mmol/l), and duration of hypoglycemia of 1.95+/-1.34 hours (range, 0.5-5.0 hours). All periods of hypoglycemia were clinically asymptomatic. Regression analysis revealed a statistically significant linear correlation (p=0.03) between blood glucose concentration and the respective 30-min activity counts. Activity counts in patients with nocturnal hypoglycemia were significantly (ANOVA, p