Burden of influenza-associated outpatient influenza-like illness consultations in China, 2006-2015: A population-based study
Burden of influenza-associated outpatient influenza-like illness consultations in China, 2006-2015: A population-based study
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DOI：
10.1111/irv.12711
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发表时间：
2019-12-23
影响因子：
4.4
通讯作者：
Lau, Eric H. Y.
中科院分区：
文献类型：
--
作者：
Feng, Luzhao;Feng, Shuo;Lau, Eric H. Y.
人类流感病毒感染每年在全世界造成相当大的发病率和死亡率负担。了解区域流感相关门诊负担对于制定流感病毒控制策略至关重要。方法提取2006 - 2015年中国30个省份流感样病例门诊哨点监测数据和哨点标本病毒学确认数据。采用广义加性回归模型估计各省流感相关的ILI门诊负担，考虑季节基线和气象因素。结果2006 - 2015年，中国30个省份每年平均每1000人-年（py）有2.5例流感与ILI过度咨询相关。与其他年份相比，2009年所有省份甲型H1N1流感pdm 09导致流感相关ILI咨询数量增加。15岁以下儿童的ILI额外负担为4.5/1000 py，明显高于成人。结论人流感病毒对人群发病率有较大影响，并造成医疗和经济负担。本研究为中国疫苗接种规划提供了依据，并为流感相关门诊咨询负担的评估提供了框架。
Background Human influenza virus infections cause a considerable burden of morbidity and mortality worldwide each year. Understanding regional influenza-associated outpatient burden is crucial for formulating control strategies against influenza viruses. Methods We extracted the national sentinel surveillance data on outpatient visits due to influenza-like-illness (ILI) and virological confirmation of sentinel specimens from 30 provinces of China from 2006 to 2015. Generalized additive regression models were fitted to estimate influenza-associated excess ILI outpatient burden for each individual province, accounting for seasonal baselines and meteorological factors. Results Influenza was associated with an average of 2.5 excess ILI consultations per 1000 person-years (py) in 30 provinces of China each year from 2006 to 2015. Influenza A(H1N1)pdm09 led to a higher number of influenza-associated ILI consultations in 2009 across all provinces compared with other years. The excess ILI burden was 4.5 per 1000 py among children aged below 15 years old, substantially higher than that in adults. Conclusions Human influenza viruses caused considerable impact on population morbidity, with a consequent healthcare and economic burden. This study provided the evidence for planning of vaccination programs in China and a framework to estimate burden of influenza-associated outpatient consultations.