Kidney Dysfunction is Associated with a High Burden of Cerebral Small Vessel Disease in Primary Intracerebral Hemorrhage
Kidney Dysfunction is Associated with a High Burden of Cerebral Small Vessel Disease in Primary Intracerebral Hemorrhage
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DOI：
10.2174/1567202615666180326094728
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发表时间：
2018-01-01
影响因子：
2.1
通讯作者：
Liu, Ming
中科院分区：
文献类型：
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作者：
Xu, Mangmang;Zhang, Shihong;Liu, Ming
目的：目的：探讨原发性脑出血（pICH）患者肾功能与脑小血管病（CSVD）总负荷的关系。方法：回顾性分析连续入选的pICH患者的脑磁共振成像，评估腔隙、白色高信号（WMH）、脑微出血（CMB）和血管周围间隙扩大（EPVS）。通过合并CSVD标志物的不同权重，对CSVD评分进行了微小改进，即改良的CSVD评分1和2。使用估计的肾小球滤过率（eGFR）评估肾功能。结果：在108例患者中，肾腔隙、CMB、MWH和基底节EPVS>10的发生率分别为27.8%、67.6%、47.2%和35.2%。在多变量有序回归中，eGFR值降低与CSVD评分增加相关[比值比（OR）0.978，95%置信区间（CI）0.962 - 0.995，P=0.013]，改良CSVD评分1（OR 0.973，95%CI 0.957 ~ 0.990，P=0.002）和2（OR 0.969，95%CI 0.953 ~ 0.986，P
Objectives: To investigate the association of kidney function with the total burden of Cerebral Small Vessel Disease (CSVD) in primary Intracerebral Hemorrhage (pICH).Methods: Cerebral magnetic resonance imagings of consecutively enrolled pICH patients were reviewed to assess for lacunes, White Matter Hyperintensity (WMH), Cerebral Microbleeds (CMBs) and Enlarged Perivascular Spaces (EPVS). Minor refinements to the CSVD score, namely modified CSVD score 1 and 2, were made by incorporating different weightings of CSVD markers. Kidney function was assessed using the estimated Glomerular Filtration Rate (eGFR). We used ordinal regression analysis to assess the association of kidney function with the CSVD score and modified scores.Results: In the 108 patients included, the presence of lacunes, CMBs, MWH and basal ganglia EPVS>10 was 27.8%, 67.6%, 47.2% and 35.2%, respectively. In multivariable ordinal regression, a decreasing eGFR value was associated with an increased CSVD score [Odds Ratio (OR) 0.978, 95% Confidence Interval (CI) 0.962 to 0.995, P=0.013], modified CSVD score 1 (OR 0.973, 95% CI 0.957 to 0.990, P=0.002) and 2 (OR 0.969, 95% CI 0.953 to 0.986, P