Associations between vitamin D and pulmonary function in chronic spinal cord injury.
Associations between vitamin D and pulmonary function in chronic spinal cord injury.
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维生素 D 与慢性脊髓损伤肺功能之间的关联。
DOI：
10.1080/10790268.2018.1432305
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Hart,JaimeE
中科院分区：
文献类型：
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作者：
Garshick,Eric;Walia,Palak;Goldstein,RebekahL;Teylan,MerileeA;Lazzari,AntonioA;Tun,CarlosG;Hart,JaimeE
背景/目的：慢性脊髓损伤（SCI）患者因呼吸系统疾病而发病和死亡的风险增加。以前在非SCI人群中的研究表明，维生素D可能是呼吸系统健康的决定因素。因此，我们试图评估，如果较低的维生素D水平与肺功能下降的人与慢性SCI.Design：横断面研究。设置：退伍军人事务部医疗Center.Participants：312名参与者（260名男性和52名女性）从VA波士顿和社区招募的慢性SCI参与流行病学研究，以评估影响呼吸health.Methods的因素：参与者提供了血液样本，完成了呼吸健康问卷，并进行肺功能测定。线性回归方法被用来评估血浆25-hydroxyviatmin D和肺功能的肺活量测定措施之间的横截面associationsofpulmonaryfunction.Outcome措施：用力呼气容积在一秒钟（FEV 1），用力肺活量（FVC），和FEV 1/FVC。结果：调整和未调整的一些混杂因素，血浆维生素D水平和FEV 1，FVC，或FEV 1/FVC之间没有显着关联。例如，在完全校正的模型中，维生素D每增加10 ng/ml，FEV 1变化4.4 ml（95%CI −64.4，73.2，P = 0.90）。结论：在慢性SCI患者队列中，血浆维生素D与FEV 1、FVC或FEV 1/FVC之间没有显著的横断面相关性。
Context/Objective:Individuals with chronic spinal cord injury (SCI) have an increased risk of morbidity and mortality attributable to respiratory diseases. Previous studies in non-SCI populations suggest that vitamin D may be a determinant of respiratory health. Therefore, we sought to assess if lower vitamin D levels were associated with decreased pulmonary function in persons with chronic SCI.Design:Cross-sectional study.Setting:Veterans Affairs Medical Center.Participants:312 participants (260 men and 52 women) with chronic SCI recruited from VA Boston and the community participating in an epidemiologic study to assess factors influencing respiratory health.Methods:Participants provided a blood sample, completed a respiratory health questionnaire, and underwent spirometry. Linear regression methods were used to assess cross-sectional associations between plasma 25-hydroxyviatmin D and spirometric measures of pulmonary function.Outcome Measures:Forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and FEV1/FVC.Results:Adjusted and unadjusted for a number of confounders, there was no significant association between plasma vitamin D levels and FEV1, FVC, or FEV1/FVC. For example, in fully adjusted models, each 10 ng/ml increase in vitamin D was associated with a 4.4 ml (95%CI −64.4, 73.2, P = 0.90) ml change in FEV1.Conclusion:There was no significant cross-sectional association between plasma vitamin D and FEV1, FVC, or FEV1/FVC in this cohort of individuals with chronic SCI.