Exposure to pyrethroid pesticides and the risk of childhood brain tumors in East China
Exposure to pyrethroid pesticides and the risk of childhood brain tumors in East China
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DOI：
10.1016/j.envpol.2016.08.066
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发表时间：
2016-11-01
影响因子：
8.9
通讯作者：
Wu, Yeming
中科院分区：
文献类型：
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作者：
Chen, Sheng;Gu, Shuo;Wu, Yeming
农药暴露被假设为儿童脑肿瘤（CBT）发展的危险因素之一。这项以医院为基础的病例对照研究评价了拟除虫菊酯农药暴露与华东地区儿童人群CBT风险的相关性。在2012年9月至2015年6月期间，从上海的2家儿童医学中心（新华医院和上海儿童医学中心）共招募了161例CBT病例和170例对照。病例组和对照组在年龄、性别和居住省份上相匹配。拟除虫菊酯农药暴露评估的3个非特异性代谢产物的拟除虫菊酯（顺式DCCA，反式DCCA，3-PBA），使用气相色谱-质谱（GC-MS）检测和管理的问卷。非条件Logistic回归分析显示，trans-DCCA、3-PBA和总代谢物（3种代谢物的总和）与CBT风险增加呈正相关。在调整混杂因素后，最高四分位数的儿童患CBT的风险比最低四分位数的儿童高出近3倍（trans-DCCA，OR = 2.58，95% CI，1.38-4.80，p = 0.003; 3-PBA，OR = 3.26，95% CI，1.73-6.14，p < 0.0001;总代谢物，OR = 3.60，95%CI，1.87-6.93，p < 0.0001）。我们还发现，接触灭蚊剂和灭蟑剂与CBT的风险增加有关（灭蚊剂，OR = 1.68，95%CI，1.06-2.67，p = 0.027;灭蟑剂，OR = 1.83，95%CI，1.13-2.95，p = 0.013）。这些发现表明，暴露于拟除虫菊酯农药可能与CBT的风险增加有关。需要更大样本量的前瞻性队列研究来证实这一结论。(C)2016爱思唯尔有限公司版权所有，
Pesticide exposure is hypothesized as one of the risk factors for the development of childhood brain tumors (CBT). This hospital-based case control study evaluated the association of pyrethroid pesticide exposure with the risk for CBT in a children population in East China. In total, 161 CBT cases and 170 controls were recruited from 2 children's medical centers in Shanghai (Xinhua Hospital and Shanghai Children's Medical Center) between September 2012 and June 2015. The cases and controls were matched for age, sex, and province of residence. Pyrethroid pesticide exposure was evaluated by urinalysis of 3 nonspecific metabolites of pyrethroids (cis-DCCA, trans-DCCA, and 3-PBA) using gas chromatography-mass spectrometry (GC-MS) detection and by administering a questionnaire. Unconditional logistic regression showed that trans-DCCA, 3-PBA, and total metabolites (sum of the 3 metabolites) were positively associated with the increased risk of CBT. Children in the highest quartile had a nearly 3-fold increased risk of CBT compared with those in the lowest quartile after adjusting for confounding factors (trans-DCCA, odds ratio (OR) = 2.58, 95% confidence interval (Cl), 1.38-4.80, p = 0.003; 3-PBA, OR = 3.26, 95% CI, 1.73-6.14, p < 0.0001; total metabolites, OR = 3.60, 95% CI, 1.87-6.93, p < 0.0001). We also found that exposure to both mosquitocide and cockroach killer was related to the increased risk of CBT (mosquitocide, OR = 1.68, 95% CI, 1.06-2.67, p = 0.027; cockroach killer, OR = 1.83, 95% CI, 1.13-2.95, p = 0.013). These findings indicate that exposure to pyrethroid pesticides might be associated with increased risk of CBT. Prospective cohort studies with larger sample sizes are required to confirm this conclusion. (C) 2016 Elsevier Ltd. All rights reserved,