Toward a miniaturized wireless fluorescence-based diagnostic Imaging system
Toward a miniaturized wireless fluorescence-based diagnostic Imaging system
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DOI：
10.1109/jstqe.2007.911765
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发表时间：
2008-01-01
影响因子：
4.9
通讯作者：
Deen, M. Jamal
中科院分区：
文献类型：
--
作者：
Kfouri, Moussa;Marinov, Ognian;Deen, M. Jamal
基于荧光的光谱学和成像技术提供了关于生物系统的定性和定量诊断信息。在本文中，我们报告的设计，制造和测试的一个小型化的无线荧光成像设备的非侵入性临床诊断和胃肠道疾病的筛查。该系统包括光学成像、电子控制与图像采集、信息处理与传输三个子模块。这些模块在集成到电池供电的无线设备之前都是单独开发和测试的。最终的集成系统安装在定制的紧凑型圆柱形外壳中。每个单独的模块和整个集成系统的性能已经使用荧光体模进行了评估。它已被证明，小型化的设备可以获得光谱分辨的荧光图像和无线传输的图像流。这项可行性研究的一个重要成果是确定了重要的技术问题和未来原型开发的途径。
Fluorescence-based spectroscopy and imaging techniques provide qualitative and quantitative diagnostic information on biological systems. In this paper, we report on the design, fabrication, and testing of a miniaturized wireless fluorescence imaging device for noninvasive clinical diagnosis and screening of diseases in the gastrointestinal tract. The system includes three submodules: optical imaging, electronics control and image acquisition, and information processing and transmission. These modules were individually developed and tested before being integrated into a battery-powered wireless device. The final integrated system is mounted in a customized, compact cylindrical housing. The performance each individual module and the overall integrated system has been evaluated using fluorescent phantoms. It has been demonstrated that the miniaturized device can acquire spectrally resolved fluorescence images and transmit the image stream wirelessly. An important outcome of this feasibility study is the identification of important technological issues and pathways for future prototype development.