Longer-term increased cortisol levels in young people with mental health problems.
Longer-term increased cortisol levels in young people with mental health problems.
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DOI：
10.1016/j.psychres.2015.12.025
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发表时间：
2016-02-28
影响因子：
11.3
通讯作者：
Wood SJ
中科院分区：
文献类型：
--
作者：
Heinze K;Lin A;Reniers RLEP;Wood SJ
在血液、唾液和尿样中的一系列精神障碍中，下丘脑-垂体-肾上腺轴活动障碍是常见的报道。这项研究旨在观察长期皮质醇水平及其与临床症状的关系。对30名16~25岁有心理健康问题的年轻人(MAGE±SD=21±2.4，26名女性)和28名健康对照(HC，MAGE±SD=20±2.9，26名女性)头发皮质醇浓度进行了分析。临床参与者完成了对精神症状、功能和生活方式因素的评估。所有参与者都完成了知觉压力量表。在过去的3个月(但不是3-6个月)，临床参与者的头发皮质醇浓度显著高于对照组。与HC相比，临床参与者在过去一个月中感受到的压力显著更高，但与头发皮质醇没有显著相关性。头发皮质醇水平与任何其他指标均无显著相关性。发段分析显示，在过去的3个月里，早期精神健康问题的皮质醇水平长期上升。要进一步了解皮质醇在精神疾病发病机制中的作用，需要进行将皮质醇与精神病理学和疾病进展联系起来的纵向研究。青少年心理健康问题患者头发皮质醇水平的调查与对照组相比，临床参与者的第一段皮质醇升高。头发皮质醇与临床指标无关。
Disturbance of hypothalamus–pituitary–adrenal axis activity is commonly reported in a range of mental disorders in blood, saliva and urine samples. This study aimed to look at longer-term cortisol levels and their association with clinical symptoms. Hair strands of 30 young people (16–25 years) presenting with mental health problems (Mage±SD=21±2.4, 26 females) and 28 healthy controls (HC, Mage±SD=20±2.9, 26 females) were analyzed for cortisol concentrations, representing the past 6 months prior to hair sampling. Clinical participants completed an assessment on psychiatric symptoms, functioning and lifestyle factors. All participants completed the Perceived Stress Scale. Hair cortisol concentrations representing the past 3 (but not 3–6) months were significantly increased in clinical participants compared to HC. Perceived stress in the past month was significantly higher in clinical participants compared to HC, but not significantly correlated with hair cortisol. Hair cortisol levels were not significantly associated with any other measures. Hair segment analyses revealed longer-term increased levels of cortisol in the past 3 months in early mental health problems. Further insight into the role of cortisol on the pathogenesis of mental illnesses requires longitudinal studies relating cortisol to psychopathology and progression of illness. Investigation of hair cortisol in young people with mental health problems. Elevated first segment cortisol in clinical participants compared to controls. Hair cortisol was not associated with clinical measures.