SATB1 is an independent prognostic marker for gastric cancer in a Chinese population
SATB1 is an independent prognostic marker for gastric cancer in a Chinese population
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SATB1是中国人群胃癌的独立预后标志物
DOI：
10.3892/or_00000945
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发表时间：
2010-10-01
期刊：
影响因子：
4.2
通讯作者：
Tong, Qiang
中科院分区：
文献类型：
--
作者：
Lu, Xiaoming;Cheng, Chao;Tong, Qiang
特异性富含AT序列结合蛋白1（SATB 1）是一种新型的基因调控因子，在多种人类肿瘤中表达，可能与肿瘤的恶性潜能有关。然而，关于SATB 1表达及其与胃癌进展的关系的数据很少。本研究旨在检测SATB 1在胃癌中的表达，并将其与临床结果相关联。分别采用qRT-PCR、Western blotting和免疫组织化学方法研究SATB 1的表达。统计分析SATB 1表达与临床病理因素的相关性。SATB 1 mRNA在胃癌组织中的表达显著高于正常组织（P
Special AT-rich sequence binding protein 1 (SATB1), a new type of gene regulator, has been reported to express in various human cancers and may associate with the malignant potential. However, there are few data available on SATB1 expression and its relationship to tumor progression in gastric cancer. The current study was designed to examine the SATB1 expression in gastric cancer and to correlate it with clinical outcome. SATB1 expression was studied by qRT-PCR, Western blotting and immunohistochemistry, respectively. The correlations between SATB1 expression and clinicopathological factors were statistically analyzed. SATB1 mRNA expression was significantly up-regulated in gastric cancer specimens as compared with that in normal tissues (P