The Edinburgh human metabolic network reconstruction and its functional analysis.
The Edinburgh human metabolic network reconstruction and its functional analysis.
复制标题
爱丁堡人类代谢网络重建及其功能分析。
DOI：
10.1038/msb4100177
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发表时间：
2007
影响因子：
9.9
通讯作者：
Goryanin, Igor
中科院分区：
文献类型：
--
作者：
Ma, Hongwu;Sorokin, Anatoly;Mazein, Alexander;Selkov, Alex;Selkov, Evgeni;Demin, Oleg;Goryanin, Igor
更好地了解人体代谢及其与疾病的关系是人类系统生物学研究的重要任务。在本文中，我们提出了一个高质量的人类代谢网络人工重建整合基因组注释信息从不同的数据库和代谢反应信息从文献。该网络包含近3000个代谢反应，根据它们的功能关系，将其重组为约70个人类特异性代谢途径。通过对网络中代谢物功能连接性的分析，再次证实了先前通过结构分析发现的蝴蝶结结构。此外，疾病相关基因在网络中的分布表明，蝴蝶结结构的IN（底物）子集比其他部分具有更大的灵活性。
A better understanding of human metabolism and its relationship with diseases is an important task in human systems biology studies. In this paper, we present a high-quality human metabolic network manually reconstructed by integrating genome annotation information from different databases and metabolic reaction information from literature. The network contains nearly 3000 metabolic reactions, which were reorganized into about 70 human-specific metabolic pathways according to their functional relationships. By analysis of the functional connectivity of the metabolites in the network, the bow-tie structure, which was found previously by structure analysis, is reconfirmed. Furthermore, the distribution of the disease related genes in the network suggests that the IN (substrates) subset of the bow-tie structure has more flexibility than other parts.