Limonoids with 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitory Activities from Dysoxylum mollissimum
Limonoids with 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitory Activities from Dysoxylum mollissimum
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DOI：
10.1021/acs.jnatprod.5b00442
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发表时间：
2015-08-01
影响因子：
5.1
通讯作者：
Yue, Jian-Min
中科院分区：
文献类型：
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作者：
Zhou, Bin;Shen, Yu;Yue, Jian-Min
从毛八角木（Dysoxylum mollissimum）的枝条中分离得到13个新的柠檬苦素类化合物，即Dysoxylumosins A-M（1-13），其中沿着6个已知的类似物（14-19）。通过波谱数据分析确定了它们的结构。化合物1-6、8和12显示出对人和/或小鼠11 β-羟基类固醇脱氢酶1型（11 β-HSD 1）的显著抑制活性。Dysoxylumosin F（6）是分离的最有效的物质，对人11 β-HSD 1的IC 50值为9.6 +/- 0.90 nM。
Thirteen new limonoids, dysoxylumosins A-M (1-13), along with six known analogues (14-19) were isolated from the twigs of Dysoxylum mollissimum. Their structures were established on the basis of spectroscopic data analysis. Compounds 1-6, 8, and 12 exhibited significant inhibitory activities against human and/or mouse 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1). Dysoxylumosin F (6), the most potent substance isolated, showed an IC50 value of 9.6 +/- 0.90 nM against human 11 beta-HSD1.