Uptake of bloodborne bacteria by pulmonary intravascular macrophages and consequent inflammatory responses in sheep.
Uptake of bloodborne bacteria by pulmonary intravascular macrophages and consequent inflammatory responses in sheep.
复制标题
绵羊肺血管内巨噬细胞摄取血源性细菌以及随后的炎症反应。
DOI：
10.1164/ajrccm/136.3.683
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Brain,JD
中科院分区：
文献类型：
--
作者：
Warner,AE;Molina,RM;Brain,JD
细菌主要通过肝脏和脾脏中的单核吞噬细胞从大多数物种的血流中清除。我们最近描述了在几种反刍动物中存在大量的肺血管内巨噬细胞，这些巨噬细胞也从血流中清除惰性颗粒。为了确定这些细胞在清除血液中细菌的作用，绵羊和大鼠静脉注射单剂量的铜绿假单胞菌，并在注射后1小时比较清除动力学、器官间相对摄取以及肺和肝的形态学变化。在大鼠中，细菌主要由肝脏去除，并且在肝涂片中发现病理变化，但在肺中未发现。然而，在绵羊中，细菌主要通过肺去除，并且肺毛细血管充满中性粒细胞、血小板和纤维蛋白沉积物。我们认为，肺血管内巨噬细胞对细菌的摄取和随后炎症介质的释放是反刍动物脓毒症诱导的成人呼吸窘迫综合征模型中产生的病理变化的核心。
Bacteria are primarily removed from the bloodstream of most species by mononuclear phagocytic cells in the liver and spleen. we have recently described large numbers of pulmonary intravascular macrophages In several ruminant species that also remove inert particles from the bloodstream. Todetermine the role ofthese cells In removal of bacteria from the bloodstream, sheep and rats were Injected intravenously with a single dose of Pseudomonas aerug/nosa, and kinetics of clearance, relative uptake among organs, and morphologic changes In the lungs and liver 1 h after injection were compared. In rats, bacteria were removed primarily by the liver, and pathologic changes were found in hepatic slnusolds but not In the lungs. However, In sheep, bacteria were removed primarily by the lungs, and pUlmonary capillaries became filled with neutrophils, platelets, and fibrin deposits. We propose that uptake of bacteria by pulmonary intravascular macrophages and subsequent release of inflammatory mediators are central to the pathologic changes produced in ruminant models of sepsis-induced adult respiratory distress syndrome.