Cutting edge:: CD1a+ antigen-presenting cells in human dermis respond rapidly to CCR7 Ligands
Cutting edge:: CD1a+ antigen-presenting cells in human dermis respond rapidly to CCR7 Ligands
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DOI：
10.4049/jimmunol.176.10.5730
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发表时间：
2006-05-15
影响因子：
4.4
通讯作者：
Dunbar, P. Rod
中科院分区：
文献类型：
--
作者：
Angel, Catherine E.;George, Elizabeth;Dunbar, P. Rod
来自鼠模型的最新数据已经证实，兰格汉斯细胞并不是涉及“启动免疫反应的皮肤中的APC群体”。在健康的人体皮肤中，我们鉴定出位于真皮上层淋巴管附近的CD1A（+）皮肤病，这些淋巴管与迁移的兰格汉细胞明确不同，但表现出有效的同种刺激能力，又表现出对CCR17配体的趋化性反应。相反，CD14（+）皮肤APC分布在整个真皮中，缺乏对CCR7配体的趋化反应。因此，CD1A（+）皮肤病代表了能够迁移到淋巴结和刺激天真T细胞的Langerhans细胞不同的APC群体。在人类中，CD1A（+）皮肤APC可能会履行以前a的某些角色，以符合Langerhans细胞。
Recent data from murine models have confirmed that Langerhans cells are not the only population of APCs in the skin involved in 'initiating immune responses. In healthy human skin, we identify CD1a(+) dermalAPCs located close to the lymphatic vessels in the upper layers of the dermis that are unequivocally distinct from migrating Langerhans cells but exhibit both potent allostimulatory capacity and a chemotactic response to CCR17 ligands. In contrast, CD14(+) dermal APCs are distributed throughout the dermis and lack a chemotactic response to CCR7 ligands. CD1a(+) dermalAPCs therefore represent an APC population distinct from Langerhans cells that are capable of migrating to lymph nodes and stimulating naive T cells. In humans, CD1a(+) dermal APCs may fulfill some of the roles previously a-scribed to Langerhans cells.