Subjective health perception in healthy young men changes in response to experimentally restricted sleep and subsequent recovery sleep
Subjective health perception in healthy young men changes in response to experimentally restricted sleep and subsequent recovery sleep
复制标题
DOI：
10.1016/j.bbi.2013.06.005
复制
发表时间：
2013-11-01
影响因子：
15.1
通讯作者：
Axelsson, John
中科院分区：
文献类型：
--
作者：
Lekander, Mats;Andreasson, Anna Nixon;Axelsson, John
睡眠和主观健康都与健康和医疗保健使用的客观指标前瞻性相关。在这里，我们测试了五天睡眠受限和随后的恢复日是否会影响主观健康，以及是否与循环 IL-6 和 TNF-α 水平升高以及疲劳有关。九名健康男性（23-28 岁）接受了为期 6 周的睡眠方案，受试者作为自己的对照，采用重复测量设计，在睡眠实验室总共 11 个晚上。该协议的实验部分包括在睡眠实验室中的三个基线天（睡眠 23-07 小时）、五天睡眠限制（03-07 小时）和三个恢复天（23-07 小时）。每天记录主观健康和疲劳。在该方案的 8 天中，每天（每三个小时）抽取 8 个血样，并进行 IL-6 和 TNF-α 分析。在睡眠受限期间，主观健康状况逐渐恶化 (p = .002)，并在恢复三天后恢复到基线水平。 IL-6和TNF-α没有显着变化。睡眠限制期间疲劳逐渐增加 (p = .001)，这显着促进了睡眠限制与主观健康之间的关联。该研究首次表明主观健康状况对睡眠长度的变化有直接反应，并且与疲劳增加有关。因此，在操纵其假定的决定因素之一后，主观健康状况会得到不同的评估。更大规模的实验研究将有利于进一步区分主观健康基础上的因果关系和关联。 (C) 2013 年，爱思唯尔公司出版。
Sleep and subjective health are both prospectively related to objective indices of health and health care use. Here, we tested whether five days with restricted sleep and subsequent recovery days affect subjective health and is related to increased levels of circulating IL-6 and TNF-alpha and fatigue. Nine healthy men (23-28 years) went through a 6-week sleep protocol with subjects as their own controls in a repeated measures design with a total of 11 nights in a sleep laboratory. The experimental part of the protocol included three baseline days (sleep 23-07 h), five days with sleep restriction (03-07 h) and three recovery days (23-07 h) in the sleep laboratory. Subjective health and fatigue was recorded daily. Eight blood samples were drawn each day (every third hour) on 8 days of the protocol and analyzed with respect to IL-6 and TNF-alpha. Subjective health deteriorated gradually during restricted sleep (p = .002) and returned to baseline levels after three days of recovery. IL-6 and TNF-alpha did not change significantly. Fatigue increased gradually during sleep restriction (p = .001), which significantly contributed to the association between restricted sleep and subjective health. The study is the first to show that subjective health is directly responsive to changes in sleep length and related to increased fatigue. Thus, subjective health is differently appraised after manipulation of one of its presumed determinants. Larger experimental studies would be beneficial to further distinguish causation from association regarding the underpinnings of subjective health. (C) 2013 Published by Elsevier Inc.