A floating metal microelectrode array for chronic implantation
A floating metal microelectrode array for chronic implantation
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DOI：
10.1016/j.jneumeth.2006.09.005
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发表时间：
2007-02-15
影响因子：
3
通讯作者：
Andersen, Richard A.
中科院分区：
文献类型：
--
作者：
Musallam, Sam;Bak, Martin J.;Andersen, Richard A.
多电极阵列的植入在神经科学研究领域变得越来越普遍，并且在临床应用中变得越来越重要。其中许多研究都是针对感觉和运动假肢的发展。在这里，我们提出了一种由生物相容性材料制成的多电极系统，该系统具有电气和机械稳定性，并采用了允许阵列内单个电极的几何布局和长度具有灵活性的设计特征。我们还采用了薄陶瓷基板激光加工的最新进展，在陶瓷上应用超细线金导体，制造极其灵活的电缆，以及在浮动多电极阵列（FMA）的开发中将金属微电极并置在几百微米内的细线管理技术。我们将FMA植入大鼠体内，发现FMA能够同时记录峰电位和局部场电位。(c) 2006 Elsevier B.V.版权所有
implantation of multi-electrode arrays is becoming increasingly more prevalent within the neuroscience research community and has become important for clinical applications. Many of these studies have been directed towards the development of sensory and motor prosthesis. Here, we present a multi-electrode system made from biocompatible material that is electrically and mechanically stable, and employs design features allowing flexibility in the geometric layout and length of the individual electrodes within the array. We also employ recent advances in laser machining of thin ceramic substrates, application of ultra-fine line gold conductors to ceramic, fabrication of extremely flexible cables, and fine wire management techniques associated with juxtaposing metal microelectrodes within a few hundred microns of each other in the development of a floating multi-electrode array (FMA). We implanted the FMA in rats and show that the FMA is capable of recording both spikes and local field potentials. (c) 2006 Elsevier B.V. All rights reserved.