Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells.
Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells.
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DOI：
10.4049/jimmunol.1501220
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发表时间：
2015-11-01
期刊：
影响因子：
--
通讯作者：
Zhuang Y
中科院分区：
文献类型：
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作者：
Zhang B;Wu J;Jiao Y;Bock C;Dai M;Chen B;Chao N;Zhang W;Zhuang Y
Dendritic Epidermal T Cells (DETCs) are generated exclusively in the fetal thymus and maintained in the skin epithelium throughout postnatal life of the mouse. DETCs have restricted antigenic specificity due to their exclusive usage of a canonical TCR. Although the importance of the TCR in DETC development has been well established, the exact role of TCR signaling in DETC homeostasis and function remains incompletely defined. Here, we investigated TCR signaling in fully matured DETCs by lineage-restricted deletion of the Lat gene, an essential signaling molecule downstream of the TCR. We found that Lat deletion impaired TCR-dependent cytokine gene activation and the ability of DETC undergoing proliferative expansion. However, LAT-deficient DETCs were able to maintain long-term population homeostasis even though with reduced proliferation rate. Mice with Lat deletion in DETCs exhibited delayed wound healing accompanied by impaired clonal expansion within the wound area. Our study revealed differential requirements of TCR signaling in homeostatic maintenance of DETCs and in their effector function during wound healing.
