Noninvasive blood glucose monitoring with optical coherence tomography - A pilot study in human subjects
Noninvasive blood glucose monitoring with optical coherence tomography - A pilot study in human subjects
复制标题
DOI：
10.2337/diacare.25.12.2263
复制
发表时间：
2002-12-01
期刊：
影响因子：
16.2
通讯作者：
Esenaliev, RO
中科院分区：
文献类型：
--
作者：
Larin, KV;Eledrisi, MS;Esenaliev, RO
目的：探讨光学相干层析成像(OCT)技术用于健康志愿者无创血糖监测的可行性。研究设计与方法：采用波长为1300 nm的OCT系统，对15名健康受试者进行18项临床实验。进行标准的口服葡萄糖耐量试验以引起血糖浓度的变化。每隔5或15分钟从右臂静脉采血一次。S在3h内每隔10-20次从左前臂采集一次OCT图像，并在距皮肤表面200-600微米处计算信号斜率。在整个实验过程中，非侵入性测量的OCT信号斜率的变化与血糖浓度之间有很好的相关性。OCT信号的斜率随血糖值的变化而显著变化(高达2.8%/10 mg/dl)。OCT信号斜率与血糖浓度之间的良好相关性是由于背向散射光子的相干检测，这使得可以测量来自特定组织层的OCT信号，而不需要来自其他组织层的有害信号。结论：这项初步研究证明了OCT技术能够非侵入性地监测人体血糖浓度。计划对包括糖尿病受试者在内的更多受试者进行进一步研究，以验证这些初步结果。
Objective-To study the feasibility of noninvasive blood glucose monitoring using optical coherence tomography (OCT) technique in healthy volunteers.Research Design and Methods-An OCT system with the wavelength of 1,300 nm was used in 15 healthy subjects in 18 clinical experiments. Standard oral glucose tolerance tests were performed to induce changes in blood glucose concentration. Blood samples were taken from the right arm vein every 5 or 15 min. OCT images were taken every 10-20 s from the left forearm over a total period of 3 h. The slope of the signals was calculated at the depth of 200-600 mum from the skin surface.Results-A total of 426 blood samples and 8,437 OCT images and signals were collected and analyzed in these experiments. There was a good correlation between changes in the slope of noninvasively measured OCT signals and blood glucose concentrations throughout the duration of the experiments. The slope of OCT signals changed significantly (up to 2.8% per 10 mg/dl) with variation of plasma glucose values. The good correlation obtained between the OCT signal slope and blood glucose concentration is due to the coherent detection of backscattered photons, which allows measurements of OCT signal from a specific tissue layer without unwanted signal from other tissue layers.Conclusions-This pilot study demonstrated the capability of the OCT technique to monitor blood glucose concentration noninvasively in human subjects. Further studies with a larger number of subjects including diabetic Subjects are planned to validate these preliminary results.