Phosphine-Catalyzed Sequential [4+3] Domino Annulation/Allylic Alkylation Reaction of MBH Carbonates: Efficient Construction of Seven-Membered Heterocycles
Phosphine-Catalyzed Sequential [4+3] Domino Annulation/Allylic Alkylation Reaction of MBH Carbonates: Efficient Construction of Seven-Membered Heterocycles
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MBH碳酸酯的膦催化顺序[4 3]多米诺成环/烯丙基烷基化反应：七元杂环的高效构建
DOI：
10.1021/acs.orglett.7b02742
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发表时间：
2017-10-20
期刊：
影响因子：
5.2
通讯作者：
Huang, You
中科院分区：
文献类型：
--
作者：
Chen, Junlong;Huang, You
报道了膦催化的MBH碳酸酯和N-对甲苯磺酰基氮杂二烯的分子间顺序[4 + 3]多米诺成环/烯丙基烷基化反应。以高产率合成了一系列苯并呋喃稠合的单季氮杂七元环化合物。在这个顺序反应中，三个新的键在一锅中形成，MBH碳酸酯同时作为1，2，3-C3合成子和Cl合成子。
Phosphine-catalyzed intermolecular sequential [4 + 3] domino annulation/allylic alkylation of MBH carbonates and N-tosyl azadienes is reported. A series of functionalized benzofuran-fused seven-membered nitrogen-heterocyclic compounds with one quaternary center were obtained in good to excellent yields. In this sequential reaction, three new bonds were formed in one pot, and the MBH carbonates serve as 1,2,3-C3 synthon and Cl synthon at the same time.