Adaptive Immune Receptor Repertoire (AIRR) Community Guide to Repertoire Analysis.
Adaptive Immune Receptor Repertoire (AIRR) Community Guide to Repertoire Analysis.
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DOI：
10.1007/978-1-0716-2115-8_17
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发表时间：
2022-01-01
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影响因子：
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通讯作者：
Stervbo, Ulrik
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文献类型：
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作者：
Marquez, Susanna;Babrak, Lmar;Stervbo, Ulrik
适应性免疫受体谱系(AIRR)含有丰富的信息，可用于深入了解免疫系统的工作原理。基因的使用、CDR3的特性、克隆谱系结构和序列多样性都能够揭示疾病、疫苗接种或其他干预措施扰动下的动态免疫反应。在这里，我们侧重于对曲目分析的许多方面进行概念性介绍，并引导读者了解每一方面的用途和优势。在此过程中，我们注意到为这些调查开发的许多软件工具中的一些，并将讨论的想法与本卷其他地方提供的方法章节联系起来。
Adaptive immune receptor repertoires (AIRRs) are rich with information that can be mined for insights into the workings of the immune system. Gene usage, CDR3 properties, clonal lineage structure, and sequence diversity are all capable of revealing the dynamic immune response to perturbation by disease, vaccination, or other interventions. Here we focus on a conceptual introduction to the many aspects of repertoire analysis and orient the reader toward the uses and advantages of each. Along the way, we note some of the many software tools that have been developed for these investigations and link the ideas discussed to chapters on methods provided elsewhere in this volume.