Developmental trajectories in children with prolonged NICU stays
Developmental trajectories in children with prolonged NICU stays
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DOI：
10.1136/archdischild-2016-310777
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发表时间：
2017-01-01
影响因子：
5.2
通讯作者：
Scharf, Rebecca J.
中科院分区：
文献类型：
--
作者：
Subedi, Dibya;DeBoer, Mark D.;Scharf, Rebecca J.
目的评价新生儿重症监护室（NICU）的长期停留出生后和儿童神经发育的措施，从9个月到kindergarten.Design纵向出生队列研究。设置和patients之间的关系本研究检查了一个全国代表性的样本10 700名参与者从早期儿童纵向样本出生队列，并选择了那些谁有NICU停留（n=2100）。这些孩子从出生到幼儿园。预测因子天在NICU.Main结果措施儿童神经发育和早期的学术scores.Results增加在NICU的逗留时间与9个月和24个月的贝利精神和运动评分有显着的负相关关系。在新生儿重症监护室中每多呆一周，贝利9个月心理测试中得分最低的10%的几率就会增加。（OR 1.08，95% CI 1.034至1.122）和运动（OR 1.11，CI 1.065至1.165）评估和24个月精神（OR 1.09，CI 1.041至1.144）和运动评估（OR 1.07 CI 1.017至1.123）。在我们的模型中，年龄与这些措施没有显着相关。增加社会经济地位有显着的正相关关系，学前班和幼儿园阅读和数学的成绩和得分在最低的10%，在这些measurement.Conclusion增加长度的新生儿重症监护室停留是预测减少儿童早期（9个月和24个月）的发展措施，而社会经济地位是一个更好的预测在以后的评估（学前班和幼儿园入学）。地理分类没有解释这些差异。这些数据可能对咨询父母在NICU停留后的潜在神经发育后果有影响。
Objective To evaluate the relationship between prolonged neonatal intensive care unit (NICU) stay after birth and childhood neurodevelopmental measures from age 9 months to kindergarten.Design Longitudinal birth cohort study.Setting and patients This study examined a nationally representative sample of 10 700 participants from the Early Childhood Longitudinal Sample Birth Cohort and selected those who had a NICU stay (n=2100). These children were followed from birth to kindergarten.Predictors Days in the NICU.Main outcome measures Childhood neurodevelopmental and early academic scores.Results Increasing length of stay in the NICU had a significant negative relationship with the 9-month and 24-month Bayley mental and motor scores. Each additional week in the NICU increased the odds of scoring in the lowest 10% on the Bayley 9-month mental (OR 1.08, 95% CI 1.034 to 1.122) and motor (OR 1.11, CI 1.065 to 1.165) assessments and 24 month mental (OR 1.09, CI 1.041 to 1.144) and motor assessments (OR 1.07 CI 1.017 to 1.123). Gestational age was not significantly related with these measures in our model. Increasing socioeconomic status had a significant positive relationship with preschool and kindergarten reading and math 'scores and a lower odds of scoring in the lowest 10% in these measures.Conclusion Increasing length of NICU stay was predictive of decreased child development measures in early childhood (9 and 24 months), while socioeconomic status was a better predictor at later assessments (preschool and kindergarten entries). Gestational category did not account for these differences. These data may have implications for counselling parents regarding potential neurodevelopmental consequences following NICU stay.