STABLE XENON CT CEREBRAL BLOOD-FLOW MEASUREMENTS COMPUTED BY A SINGLE COMPARTMENT DOUBLE INTEGRATION MODEL IN NORMAL AGING AND DEMENTIA
STABLE XENON CT CEREBRAL BLOOD-FLOW MEASUREMENTS COMPUTED BY A SINGLE COMPARTMENT DOUBLE INTEGRATION MODEL IN NORMAL AGING AND DEMENTIA
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DOI：
10.1097/00004728-198210000-00010
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发表时间：
1982-01-01
影响因子：
1.3
通讯作者：
MORTEL, KF
中科院分区：
文献类型：
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作者：
AMANO, T;MEYER, JS;MORTEL, KF
使用单室分析模型开发了程序，提供了局部脑血流量(LCBF)和局部组织的值的快速计算机推导：血液分配系数(L.lambda)。以吸入稳定Xe气体(Xes)为指标。这些计划计划利用在吸入35%XES后3分钟至9分钟之间进行的系列计算机断层扫描得出的原始数据点，同时同时监测呼气末XES(PEXes)的浓度。双重积分和最小二乘拟合允许在XES饱和期间的每个扫描间隔估计相应的动脉(根据PEXs)和组织XES浓度。L.lambda的派生估计。并且每个感兴趣区域的LCBF值在数学上近似于饱和到无穷大的值。所述方法可用于任何自由扩散指示剂。对13名年龄在20岁到80岁之间的正常健康志愿者的横断面分析结果显示，L.lambda没有年龄相关的变化。皮质、基底节、白质血流量随年龄增长呈进行性下降趋势。与年龄匹配的正常志愿者相比，阿尔茨海默病患者的S型老年期痴呆的LCBF值无明显变化，但皮质和丘脑灰质的LCBF值显著降低。
Programs were developed, using a single compartmental analysis model, that provide rapid computer derivation for values of both local cerebral blood flows (LCBF) and local tissue:blood partition coefficients (L.lambda.) using inhaled stable Xe gas (Xes) as the indicator. These programs are planned for utilization of raw data points derived from serial computed tomography scans made between the 3rd and 9th min after 35% Xes inhalation, while concentrations of end-tidal Xes (PEXes) are concurrently monitored. Double integration and least squares fitting permitted estimation of corresponding arterial (assumed from PEXs) and tissue Xes concentrations at each scanning interval during Xes saturation. Derived estimates for L.lambda. and LCBF values for each region of interest mathematically approximate values saturated to infinity. The method described can be utilized for any freely diffusible indicator. Cross-sectional analysis of results obtained in 13 normal healthy volunteers between 20 and 80 yr of age showed no age-related changes in L.lambda. values but progressive decreases in blood flow of cortex, basal ganglia and white matter with advancing age. In senile dementia of Alzheimer''s type (SDAT, n = 8) L.lambda. values were likewise unchanged, but cortical and thalamic gray matter LCBF values were significantly reduced compared to age-matched normal volunteers.