Ultrasonic vocalizations as an index of social memory in female mice
Ultrasonic vocalizations as an index of social memory in female mice
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DOI：
10.1037//0735-7044.115.4.834
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发表时间：
2001-08-01
影响因子：
1.9
通讯作者：
Moles, A
中科院分区：
文献类型：
--
作者：
D'Amato, FR;Moles, A
在雌性小鼠身上研究了超声发声(UV)作为社会记忆的一种测量方法。一名居民女性在同性伴侣在场的情况下发射的紫外线在3分钟的预试社交互动中进行了测量。在第二个3分钟的测试过程中，小鼠被重新暴露在熟悉的伴侣面前，或者被呈现给一个新的伴侣。在第一种情况下，当两次实验之间的间隔为15、30或60分钟时，驻留小鼠发射的紫外线减少。24小时后。这种效应消失了。相比之下，在有新的女性伴侣的情况下，UV的数量保持不变。东莨菪碱(0.05 mg/kg ip)破坏了这一记忆过程：30分钟后，接受药物治疗的雌性动物在再次接触熟悉的雌性动物时，没有表现出预期的UV减少。这项研究提供了行为和药理学证据，证明超声波叫声可以用来衡量雌性小鼠的社会记忆。
Ultrasonic vocalization (UV) as a measure of social memory was investigated in female mice. UVs emitted by a resident female in the presence of a same-sex partner were measured during a 3-min, pretest social interaction. In a second 3-min test session, mice were reexposed to the familiar partner or presented with a novel partner. In the first case, there was a decline in UVs emitted by resident mice when the intervals between the 2 sessions were 15, 30, or 60 min. After 24 hr. this effect disappeared. In contrast, with a novel female partner, the number of UVs remained unchanged. Scopolamine (0.05 mg/kg ip) disrupted this memory process: Drug-treated females did not show the expected decrease in UVs when reexposed to the familiar female after 30 min. This study provides behavioral and pharmacological evidence that ultrasonic calls can be used as a measure of social memory in female mice.