Symposium Overview-Food Addiction: Fact or Fiction?
Symposium Overview-Food Addiction: Fact or Fiction?
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DOI：
10.3945/jn.108.097691
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发表时间：
2009-03-01
影响因子：
4.2
通讯作者：
Grigson, Patricia S.
中科院分区：
文献类型：
--
作者：
Corwin, Rebecca L.;Grigson, Patricia S.
食物成瘾是一个普遍的，但有争议的话题，最近在非专业媒体和科学文献中都得到了关注。本系列文章的目的是使用临床前和临床数据的组合来确定食物是否会成瘾，如滥用药物，成瘾发展的条件以及潜在的神经生理学底物。已被用于治疗人类疾病和指导人类和动物的研究成瘾的操作定义，并提供了研讨会文章的概述。我们提出，特定的食物，特别是那些富含脂肪和/或糖的食物，在某些条件下能够促进“成瘾”样行为和神经元的变化。也就是说，这些食物虽然非常可口，但本身并不上瘾，而是在限制/狂欢消费模式之后变得如此。这种完成模式与共病的风险增加有关，如肥胖、早期体重增加、抑郁、焦虑和药物滥用，以及与复发和治疗挑战有关。因此，食物成瘾的主题值得研究，以开发新的临床干预方法，并促进我们对失控的基本机制的理解。J.营养139：617-619，2009.
Food addiction is a pervasive, yet controversial, topic that has gained recent attention in both lay media and the scientific literature. The goal of this series of articles is to use a combination of preclinical and clinical data to determine whether foods, like drugs of abuse, can be addictive, the conditions under which the addiction develops, and the underlying neurophysiological substrates. Operational definitions of addiction that have been used in the treatment of human disorders and to guide research in both humans and animals are presented, and an overview of the symposium articles is provided. We propose that specific foods, especially those that are rich in fat and/or sugar, are capable of promoting "addiction"-like behavior and neuronal change under certain conditions. That is, these foods, although highly palatable, are not addictive per se but become so following a restriction/binge pattern of consumption. Such consummatory patterns have been associated with increased risk for comorbid conditions such as obesity, early weight gain, depression, anxiety, and substance abuse as well as with relapse and treatment challenges. The topic of food addiction bears study, therefore, to develop fresh approaches to clinical intervention and to advance our understanding of basic mechanisms involved in loss of control. J. Nutr. 139: 617-619, 2009.