ABSENCE OF INTERACTION BETWEEN DELTA9-TETRAHYDROCANNABINOL (DELTA9-THC) AND CANNABIDIOL (CBD) IN AGGRESSION, MUSCLE CONTROL AND BODY-TEMPERATURE EXPERIMENTS IN MICE
ABSENCE OF INTERACTION BETWEEN DELTA9-TETRAHYDROCANNABINOL (DELTA9-THC) AND CANNABIDIOL (CBD) IN AGGRESSION, MUSCLE CONTROL AND BODY-TEMPERATURE EXPERIMENTS IN MICE
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DOI：
10.1007/bf00421075
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发表时间：
1975-01-01
期刊：
影响因子：
--
通讯作者：
DEJONG, Y
中科院分区：
文献类型：
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作者：
HAM, MT;DEJONG, Y
本文给出了大麻成分Delta9-四氢大麻酚(THC)和大麻二酚(CBD)对小鼠影响的一些实验结果。THC对隔离小鼠产生剂量依赖性的攻击性抑制，对关在笼子里的小鼠产生剂量依赖性的体温抑制。这种药物并没有改变运动的协调性。CBD对攻击性的影响很小，不显著，对体温和肌肉控制没有影响。用不同剂量的THC和CBD复配进行DAME实验。在这些实验中，两种化合物之间没有相互作用。这意味着只能有相加的作用，而不能在药理学意义上增强作用。这也意味着CBD在体外对药物代谢酶的抑制，负责THC的生物转化。还不足以在活着的动物身上引起THC的改变效应。
In this report we give the results of some experiments on the effects of the hashish constituents delta9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on mice. THC produced a dose dependent depression of aggression in isolated mice and a dose dependent depression of body temperature in group caged mice. The drug did not alter motor co-ordination. CBD showed a small, not significant influence on aggressiveness, and no in fluence on body temoerature and muscle control. The dame experiments were carried out with combinations of THC and CBD in several dosages. In these experiments no interaction between both compounds was seen. This means that there can only be an additive action and not potentiation in the pharmacological sense. It also means that the in vitro inhibition by CBD of the drug metabolizing enzymes, responsible for biotransformation of THC. is not strong enough to result in changed effects of THC in the living animal.