Analysis of airway fluid protein concentration in neurogenic pulmonary edema.
Analysis of airway fluid protein concentration in neurogenic pulmonary edema.
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神经源性肺水肿气道液体蛋白浓度分析。
DOI：
10.1152/jappl.1987.62.2.470
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Maron,MB
中科院分区：
文献类型：
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作者：
Maron,MB
脑室注射藜芦碱(40微克/公斤)可引起犬暴发性神经源性肺水肿。为了确定水肿是由微血管压升高还是通透性增加引起的，比较了已知分子半径(37-114A)的总蛋白质和内源性蛋白质组分(已知分子半径37-114A)在由藜芦碱、四氧嘧啶(通透性水肿)或左房压力和容量超负荷(血流动力学水肿)引起的犬的气道液/血浆蛋白浓度比(A/P)。给予四氧嘧啶后A/P比值较高(0.98+/-0.05)，而血流动力学水肿组A/P比值较低(0.54+/-0.04)。A/P比值在服用藜芦碱后观察到，在这些极端之间形成了一个连续体(0.48-0.84)。具有高总A/P比率的Veratine动物所有蛋白质组分的A/P比率都较高，而总A/P比率较低的动物的A/P蛋白质组分比率与血液动力学组相似。这些数据表明，血流动力学和通透性增加机制可能在这种形式的NPE的发展过程中发挥不同程度的作用。
Intracisternal administration of veratrine (40 micrograms/kg) in the alpha-chloralose-anesthetized dog produces fulminant neurogenic pulmonary edema (NPE). To determine whether the edema resulted from increased microvascular pressure or from increased permeability, the airway fluid-to-plasma protein (A/P) concentration ratios were compared for both total proteins and endogenous protein fractions of known molecular radii (37–114 A) from dogs with edema produced by either veratrine, alloxan (permeability edema), or combined left atrial pressure and volume overload (hemodynamic edema). High A/P ratios (0.98 +/- 0.05) were observed after alloxan administration, whereas lower values (0.54 +/- 0.04) were observed in hemodynamic edema. A/P ratios were observed after veratrine administration that formed a continuum (0.48–0.84) between these extremes. Veratrine animals with high overall A/P ratios exhibited elevated A/P ratios for all protein fractions, whereas animals with lower overall A/P ratios exhibited A/P protein fraction ratios similar to those observed in the hemodynamic group. These data indicate that both hemodynamic and increased permeability mechanisms may play a role to varying degrees in the development of this form of NPE.