The Use of the Gaps-In-Noise Test as an Index of the Enhanced Left Temporal Cortical Thinning Associated with the Transition between Mild Cognitive Impairment and Alzheimer's Disease
The Use of the Gaps-In-Noise Test as an Index of the Enhanced Left Temporal Cortical Thinning Associated with the Transition between Mild Cognitive Impairment and Alzheimer's Disease
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DOI：
10.3766/jaaa.16075
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发表时间：
2017-05-01
影响因子：
1.2
通讯作者：
Chermak, Gail D.
中科院分区：
文献类型：
--
作者：
Iliadou, Vasiliki (Vivian);Bamiou, Doris-Eva;Chermak, Gail D.
背景：听觉感知和认知之间已知的联系在认知测试中经常被忽视。目的：评价轻度认知障碍（MCI）老年人的听觉感知能力。研究设计：听觉感知的横断面研究。研究样本：患有轻度认知障碍的成年人和没有记录的认知问题且听力灵敏度和年龄相匹配的成年人。数据收集：对两组患者的听觉感知进行评估，评估听力敏感性、咿呀学语（SinB）和时间分辨率。结果：Mann Whitney测试显示MCIs双耳的SinB和时间分辨能力得分明显低于正常对照。gap - in Noise (GIN) Test的右耳间隙检测阈值在两组之间有明显差异（p < 0.001），没有重叠值。左耳结果两组间差异有统计学意义（p < 0.01）；然而，存在类似于8毫秒阈值的小程度重叠。除了左耳注意力不集中指数在两组之间的分布相似外，mci组的冲动和注意力不集中指数都高于对照组。结论：该研究结果支持中枢性听觉处理评估在老年人群中作为一种有希望的工具来实现痴呆症的早期诊断，同时确定中枢性听觉处理缺陷可能导致MCI患者群体的沟通缺陷。时间分辨率（GIN）的测量可能提供一个早期的，尽管是间接的，反映与MCI和阿尔茨海默病之间过渡相关的左颞叶皮质变薄的测量。
Background: The known link between auditory perception and cognition is often overlooked when testing for cognition.Purpose: To evaluate auditory perception in a group of older adults diagnosed with mild cognitive impairment (MCI).Research Design: A cross-sectional study of auditory perception.Study Sample: Adults with MCI and adults with no documented cognitive issues and matched hearing sensitivity and age.Data collection: Auditory perception was evaluated in both groups, assessing for hearing sensitivity, speech in babble (SinB), and temporal resolution.Results: Mann Whitney test revealed significantly poorer scores for SinB and temporal resolution abilities of MCIs versus normal controls for both ears. The right-ear gap detection thresholds on the Gaps-In Noise (GIN) Test clearly differentiated between the two groups (p < 0.001), with no overlap of values. The left ear results also differentiated the two groups (p < 0.01); however, there was a small degree of overlap similar to 8-msec threshold values. With the exception of the left-ear inattentiveness index, which showed a similar distribution between groups, both impulsivity and inattentiveness indexes were higher for the MCIs compared to the control group.Conclusions: The results support central auditory processing evaluation in the elderly population as a promising tool to achieve earlier diagnosis of dementia, while identifying central auditory processing deficits that can contribute to communication deficits in the MCI patient population. A measure of temporal resolution (GIN) may offer an early, albeit indirect, measure reflecting left temporal cortical thinning associated with the transition between MCI and Alzheimer's disease.