Angiotensin-converting enzyme inhibitor-induced angioedema: Late onset, irregular course, and potential role of triggers
Angiotensin-converting enzyme inhibitor-induced angioedema: Late onset, irregular course, and potential role of triggers
复制标题
DOI：
10.1111/j.1398-9995.1997.tb01024.x
复制
发表时间：
1997-04-01
期刊：
影响因子：
12.4
通讯作者：
Bircher, AJ
中科院分区：
文献类型：
--
作者：
Schiller, PI;Messmer, SL;Bircher, AJ
Angioedema is a rare but potentially life-threatening adverse effect of angiotensin-converting enzyme inhibitors (ACEI) which usually occurs within the first weeks of therapy. We report three patients in whom ACEI-induced angioedema began with a late onset of 12-33 months, and who had an irregular, unpredictable course under ACEI therapy In two patients, other drugs or trauma appeared to trigger some of the episodes. After withdrawal of the ACEI, the trigger drugs were well tolerated in provocation tests and upon re-exposure. To avoid putting some patients unnecessarily at risk for long periods, one should consider this irregular pattern of ACEI-induced angioedema and regularly monitor patients for this adverse effect.
