Association of waist circumference with risk of hypertension and type 2 diabetes in Nigerians, Jamaicans, and African-Americans
Association of waist circumference with risk of hypertension and type 2 diabetes in Nigerians, Jamaicans, and African-Americans
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DOI：
10.2337/diacare.21.11.1836
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发表时间：
1998-11-01
期刊：
影响因子：
16.2
通讯作者：
Forrester, T
中科院分区：
文献类型：
--
作者：
Okosun, IS;Cooper, RS;Forrester, T
目的 - 先前的研究表明，腰围与内脏脂肪组织的相关性更好，并且比 BMI 和腰臀比更能预测心血管疾病。在这项研究中，我们重新审视了来自三个不同环境的非洲裔人群中腰围尺寸对高血压和 2 型糖尿病风险的影响。 研究设计和方法 - 对来自尼日利亚、牙买加和美国的 5,042 名 25-74 岁男性和女性进行了横断面调查。使用多元线性回归分析评估了腰围、血压和空腹血糖之间的关系。使用特定海洋经验腰围切点的逻辑回归分析来确定高血压和成熟2型糖尿病的风险。结果 - 腰围与血压和空腹血糖呈正相关（P < 0.05）。根据从性别特异性逻辑回归模型获得的年龄调整比值比估计，腰围四分位数的增加与三个人群患高血压的风险显着相关。通过比较腰围最低和最高四分位数，观察到患 2 型糖尿病的风险高度升高（牙买加男性为 10 倍，非裔美国女性为 23 倍） 结论：如果这些人群的腰围减小，则可以大幅减少男性和女性的高血压和糖尿病。旨在通过改变生活方式（包括运动和饮食）来减少腰围的干预计划可能对降低这些人群高血压和成人糖尿病的发病率具有重要的公共卫生意义。
OBJECTIVE - Prior studies have supported that waist circumference correlates better with visceral adipose tissue and is a better predictor of cardiovascular disease than are BMI and waist-to-hip ratio. In this study, we reexamine the role of waist size on the risk of hypertension and type 2 diabetes in African-origin populations from three contrasting environments.RESEARCH DESIGN AND METHODS - A cross-sectional survey was conducted of 5,042 men and women 25-74 years of age from Nigeria, Jamaica, and the U.S. The relationship between waist, blood pressure, and fasting blood glucose was assessed using multiple linear regression analyses. Logistic regression analyses using sea-specific empirical waist cut-points were used to determine the risks of hypertension and ripe 2 diabetes.RESULTS - Waist circumference was positively correlated with blood pressure and fasting blood glucose (P < 0.05). Increasing waist quartiles were significantly associated with higher risks of hypertension in the three populations, as estimated from age-adjusted odds ratios obtained from sex-specific logistic regression models. A highly elevated risk of type 2 diabetes-10-fold for Jamaican men and 23-fold for African-American women-was observed in the comparison of lowest to highest quartiles of waist circumferenceCONCLUSIONS - Substantial reduction in hypertension and diabetes in men and women is achievable if the waist size is decreased in these populations. Intervention programs designed to reduce waist circumference through lifestyle modification, including exercise and diet, may have significant public health significance in reducing the incidence of hypertension and adult-onset diabetes in these populations.