Prospects for adoptive T cell therapy.
Prospects for adoptive T cell therapy.
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DOI：
10.1016/s0952-7915(97)80052-0
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发表时间：
1997-10
影响因子：
7
通讯作者：
C. Yee;S. Riddell;P. Greenberg
中科院分区：
文献类型：
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作者：
C. Yee;S. Riddell;P. Greenberg
自从建立了分离编码细胞毒性T淋巴细胞定义的肿瘤抗原的基因的方法以来，已经鉴定了几种抗原，并将其表征为适合作为免疫治疗的靶抗原。针对这些抗原产生T细胞的创新策略的发展，以及从病毒疾病过继免疫疗法的临床试验中吸取的经验教训，应该有助于设计针对癌症的特定过继免疫疗法的临床试验。
Since the establishment of methods to isolate genes encoding cytotoxic T lymphocyte defined tumor antigens, several antigens have been identified and characterized for suitability as target antigens for immunotherapy. The development of innovative strategies to generate T cells targeting these antigens and lessons learned from clinical trials of adoptive immunotherapy of viral diseases should facilitate the design of clinical trials for specific adoptive immunotherapy of cancer.