RISK-FACTORS FOR OVARIAN-CANCER - A CASE CONTROL STUDY
RISK-FACTORS FOR OVARIAN-CANCER - A CASE CONTROL STUDY
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DOI：
10.1038/bjc.1989.320
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发表时间：
1989-10-01
影响因子：
8.8
通讯作者：
SMITH, P
中科院分区：
文献类型：
--
作者：
BOOTH, M;BERAL, V;SMITH, P
1978年10月至1983年2月，在伦敦和牛津进行了一项以医院为基础的卵巢癌病例对照研究。比较了235名组织学诊断为上皮性卵巢癌的女性和451名对照组的月经特征、生殖和避孕史以及各种环境因素暴露史。高妊娠、子宫切除术、女性绝育和口服避孕药的使用与卵巢癌风险降低有关。不孕症和更年期较晚与风险增加有关。虽然这些因素是相关的，但在调整了其他因素的影响后，它们都被发现与卵巢癌风险独立相关。
A hospital-based case-control study of ovarian cancer was conducted in London and Oxford between October 1978 and February 1983. Menstrual characteristics, reproductive and contraceptive history and history of exposure to various environmental factors were compared between 235 women with histologically diagnosed epithelial ovarian cancer and 451 controls. High gravidity, hysterectomy, female sterilization and oral contraceptive use were associated with a reduced risk ovarian cancer. Infertility and late age at menopause were associated with an increase in risk. While these factors were related, they were each found to be independently associated with ovarian cancer risk after adjusting for the effect of the other factors.