Modeling and Characterization of an in Situ Wet Mill Operation
Modeling and Characterization of an in Situ Wet Mill Operation
复制标题
原位湿磨操作的建模和表征
DOI：
--
复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Z. Nagy
中科院分区：
文献类型：
--
作者：
David Acevedo;V. Kamaraju;B. Glennon;Z. Nagy
研究了原位湿磨和连续混合悬浮液混合产物去除结晶器（MSMPR）的集成，用于从异丙醇混合水溶液中冷却结晶对乙酰氨基酚。使用聚焦光束反射测量（FBRM）监测连续操作以确定稳态的开始。研究了现场连续磨和MSMPR装置的各种操作条件的影响。该文件表明，操作条件（即，停留时间、操作温度）影响可获得的稳态产物特性。此外，现场磨机操作条件（即，转子转速）对重要产品和工艺质量（例如平均粒度、产率和颗粒数）的影响。此外，破碎的内核进行了评估和验证，通过参数估计程序。现场轧制过程可以被认为是一个组合的n…
The integration of an in situ wet mill and continuous mixed suspension mixed product removal crystallizer (MSMPR) is studied in this work for the cooling crystallization of paracetamol from an aqueous isopropanol mixture. The continuous operation was monitored using focused beam reflectance measurements (FBRM) to determine the onset of the steady state. The impact of various operational conditions of both continuous in situ mill and MSMPR unit is studied. The paper demonstrates that the operational conditions (i.e., residence time, operational temperature) of the crystallization process affect the achievable steady state product characteristics. In addition, the influence of in situ mill operating conditions (i.e., rotor speed) on important product and process qualities such as mean particle size, yield, and particle number is also discussed. Furthermore, breakage kernels were evaluated and validated through a parameter estimation routine. The in situ mill process can be assumed to be a combination of a n...