Force-mediated molecule release from double network hydrogels
Force-mediated molecule release from double network hydrogels
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DOI：
10.1039/d1cc02726c
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发表时间：
2021-07-30
影响因子：
4.9
通讯作者：
Kilian, Kristopher Alan
中科院分区：
文献类型：
--
作者：
Jayathilaka, Pavithra Bhakthi;Molley, Thomas Gregory;Kilian, Kristopher Alan
将机械敏感连接引入到聚合物中，使得材料具有动态力响应性。在这里，我们报道了氧杂冰片二烯交联型双网络水凝胶，它通过力中介的逆Diels-Alder反应释放分子。与纯聚合物体系相比，聚丙烯酰胺和海藻酸盐的分子设计和坚韧的双网络以更小的作用力显著促进了更高的活性。在生理上相关的力的激活为在软生物材料中灌输动态机械力化学行为提供了范围。
The incorporation of mechanosensitive linkages into polymers has led to materials with dynamic force responsivity. Here we report oxanorbornadiene cross-linked double network hydrogels that release molecules through a force-mediated retro Diels-Alder reaction. The molecular design and tough double network of polyacrylamide and alginate promote significantly higher activation at substantially less force than pure polymer systems. Activation at physiologically relevant forces provides scope for instilling dynamic mechanochemical behavior in soft biological materials.