Preferential cytotoxicity of caffeic acid phenethyl ester analogues on oral cancer cells
Preferential cytotoxicity of caffeic acid phenethyl ester analogues on oral cancer cells
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DOI：
10.1016/s0304-3835(00)00389-x
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发表时间：
2000-05-29
期刊：
影响因子：
9.7
通讯作者：
Yang, CC
中科院分区：
文献类型：
--
作者：
Lee, YJ;Liao, PH;Yang, CC
作为我们先前寻找具有更好的生物活性(包括抗生素、抗病毒、抗炎和抑制肿瘤生长活性)的新化合物的一部分，我们以商用咖啡酸为原料合成了一些咖啡酸苯乙酯(CAPE)类化合物。用四甲基偶氮唑蓝(3-(4，5-dimethylthiazol-2-yl)-2，5-diphenyltetrazolium)比色法检测了9种化学物质对口腔黏膜成纤维细胞、口腔粘膜下成纤维细胞、牙龈癌颈转移细胞和舌鳞状细胞癌细胞生长的影响。CAFE及其乙基类似物对OSF、GNM和TSCCa细胞有明显的细胞毒作用，而对BF细胞无明显作用。结果表明，CAFE类化合物可能是治疗口腔癌的潜在化疗药物。(C)2000由爱思唯尔科学爱尔兰有限公司出版。保留所有权利。
As part of our previous search for new compounds with improved biological activities including antibiotic, antiviral, antiinflammatory, and tumor growth inhibition activities, we synthesized some caffeic acid phenethyl ester (CAPE)-like compounds from commercially available caffeic acid. Nine chemicals were tested by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay on the growth of buccal mucosal fibroblast (BF), oral submucosus fibroblast (OSF), neck metastasis of Gingiva carcinoma (GNM), and tongue squamous cell carcinoma (TSCCa) cells. CAFE and its ethyl analogue show significant cytotoxicity on OSF, GNM, and TSCCa cells, but not on BF cells. The results suggest that CAFE-like compounds may be potential chemotherapy agents against oral cancer. (C) 2000 Published by Elsevier Science Ireland Ltd. All rights reserved.