Nocarbenzoxazoles A-G, Benzoxazoles Produced by Halophilic Nocardiopsis lucentensis DSM 44048
Nocarbenzoxazoles A-G, Benzoxazoles Produced by Halophilic Nocardiopsis lucentensis DSM 44048
复制标题
诺卡苯并恶唑 A-G，由嗜盐诺卡氏菌 DSM 44048 产生的苯并恶唑
DOI：
10.1021/acs.jnatprod.5b00031
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发表时间：
2015-08-01
影响因子：
5.1
通讯作者：
Lu, Chunhua
中科院分区：
文献类型：
--
作者：
Sun, Mingwei;Zhang, Xiaomei;Lu, Chunhua
Seven new benzoxazole derivatives, nocarbenzoxazoles A-G (1-7), were isolated from the halophilic strain Nocardiopsis lucentensis DSM 44048. Their structures were elucidated on the basis of ID and 2D NMR spectroscopic data, HRESIMS, and X-ray single-crystal diffraction. The isolated compounds were assayed for their cytotoxicity against a panel of human tumor cell lines (HepG2, MDA-MB-23I, MDA-MB-435, HeLa, and PC3). Compounds 1-6 were found to have modest or no activity. Compound 7 showed selective activity against HepG2 and HeLa with IC50 values of 3 and 1 mu M, respectively.
