Lack of a Co-Promotion Effect of 60 Hz Circularly Polarized Magnetic Fields on Spontaneous Development of Lymphoma in AKR Mice
Lack of a Co-Promotion Effect of 60 Hz Circularly Polarized Magnetic Fields on Spontaneous Development of Lymphoma in AKR Mice
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DOI：
10.1002/bem.20538
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发表时间：
2010-02-01
影响因子：
1.9
通讯作者：
Myung, Sung-Ho
中科院分区：
文献类型：
--
作者：
Chung, Moon-Koo;Yu, Wook-Joon;Myung, Sung-Ho
本研究旨在探讨60 Hz圆极化磁场（MFs）作为AKR小鼠遗传性淋巴瘤启动子的可能作用。将160只雌性动物分为4个不同的组。他们被暴露在四种不同强度的圆偏振MF中。从4-6周龄至44- 4 - 6周龄，动物每天21小时暴露于60 Hz圆极化MF，场强（均方根值）为0 μ T（假手术对照，T1，组I）、5 μ T（T2，组II）、83.3 μ T（T3，组III）或500 μ T（T4，组IV）。在平均存活时间、临床体征、体重、血液学值、微核试验、基因表达阵列、细胞凋亡分析和尸检结果方面均未出现与手术相关的变化。在组织病理学检查中，在所有组中均观察到淋巴瘤。假手术对照组、5、83.3和500 mu T组的肿瘤发生率分别为31/40（78%）、30/40（75%）、32/40（80%）和31/40（78%）。然而，假手术对照组（T1）和圆偏振MF暴露组（T2-T4）之间的肿瘤发生率无差异。总之，没有证据表明暴露于60 Hz圆极化MF强度高达500 mu T促进AKR小鼠淋巴瘤。Bioelectromagnetics 31：130-139，2010. (C)2009威利-利斯公司
The present study was conducted to investigate the possible effect of 60 Hz circularly polarized magnetic fields (MFs) as promoters of genetically initiated lymphoma in AKR mice. One hundred sixty female animals were divided into four different groups. They were exposed to four different intensities of circularly polarized MFs. Animals received exposure to 60 Hz circularly polarized MF at field strengths (rms-value) of 0 mu T (sham control, T1, Group I), 5 mu T(T2, Group II), 83.3 mu T (T3, Group III), or 500 mu T(T4, Group IV), for 21 h/day from the age of 4-6 weeks to the age of 44-46 weeks. There were no exposure-related changes in mean survival time, clinical signs, body weights, hematological values, micronucleus assay, gene expression arrays, analysis of apoptosis, and necropsy findings. At histopathological examination, lymphoma was seen in all the groups. The tumor incidence was 31/40(78%), 30/40(75%), 32/40(80%), and 31/40(78%) in sham control, 5, 83.3, and 500 mu T groups, respectively. However, there were no differences in the tumor incidence between the sham control (T1) and circularly polarized MF exposure groups (T2-T4). In conclusion, there was no evidence that exposure to 60 Hz circularly polarized MF strengths up to 500 mu T promoted lymphoma in AKR mice. Bioelectromagnetics 31:130-139, 2010. (C) 2009 Wiley-Liss, Inc.